Heptameric targeting ligands against EGFR and HER2 with high stability and avidity.

Heptameric targeting ligands against EGFR and HER2 with high stability and avidity.

Multivalency of targeting ligands provides significantly increased binding strength towards their molecular targets. Here, we report the development of a novel heptameric targeting system, with general applications, constructed by fusing a target-binding domain with the heptamerization domain of the...

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Bibliographic Details
Main Authors: Dongwook Kim, Yitang Yan, C Alexander Valencia, Rihe Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3415411?pdf=render

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