The vascular role of CGRP: a systematic review of human studies
Intravenous infusion of human alpha calcitonin gene-related peptide (h-α-CGRP) has been applied to explore migraine pathogenesis and cerebral hemodynamics during the past three decades. Cumulative data implicate h-α-CGRP in regulating the vascular tone. In this systematic review, we searched PubMed...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1204734/full |
| _version_ | 1797785669484937216 |
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| author | Mohammad Al-Mahdi Al-Karagholi Veberka Kalatharan Peter Schunck Fagerberg Faisal Mohammad Amin |
| author_facet | Mohammad Al-Mahdi Al-Karagholi Veberka Kalatharan Peter Schunck Fagerberg Faisal Mohammad Amin |
| author_sort | Mohammad Al-Mahdi Al-Karagholi |
| collection | DOAJ |
| description | Intravenous infusion of human alpha calcitonin gene-related peptide (h-α-CGRP) has been applied to explore migraine pathogenesis and cerebral hemodynamics during the past three decades. Cumulative data implicate h-α-CGRP in regulating the vascular tone. In this systematic review, we searched PubMed and EMBASE for clinical studies investigating the vascular changes upon intravenous infusion of h-α-CGRP in humans. A total of 386 studies were screened by title and abstract. Of these, 11 studies with 61 healthy participants and 177 participants diagnosed with migraine were included. Several studies reported hemodynamic effects including flushing, palpitation, warm sensation, heart rate (HR), mean arterial blood pressure (MABP), mean blood flow velocity of middle cerebral artery (mean VMCA), and diameter of superficial temporal artery (STA). Upon the start of h-α-CGRP infusion, 163 of 165 (99%) participants had flushing, 98 of 155 (63%) participants reported palpitation, and 160 of 165 (97%) participants reported warm sensation. HR increased with 14%–58% and MABP decreased with 7%–12%. The mean VMCA was decreased with 9.5%–21%, and the diameter of the STA was dilated with 41%–43%. The vascular changes lasted from 20 to >120 min. Intravenous infusion of h-α-CGRP caused a universal vasodilation without any serious adverse events. The involvement of CGRP in the systemic hemodynamic raises concerns regarding long-term blockade of CGRP in migraine patients with and without cardiovascular complications. |
| first_indexed | 2024-03-13T00:57:16Z |
| format | Article |
| id | doaj.art-9771e6fb013142e68a29421df48bc7d2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T00:57:16Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-9771e6fb013142e68a29421df48bc7d22023-07-06T18:11:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.12047341204734The vascular role of CGRP: a systematic review of human studiesMohammad Al-Mahdi Al-KaragholiVeberka KalatharanPeter Schunck FagerbergFaisal Mohammad AminIntravenous infusion of human alpha calcitonin gene-related peptide (h-α-CGRP) has been applied to explore migraine pathogenesis and cerebral hemodynamics during the past three decades. Cumulative data implicate h-α-CGRP in regulating the vascular tone. In this systematic review, we searched PubMed and EMBASE for clinical studies investigating the vascular changes upon intravenous infusion of h-α-CGRP in humans. A total of 386 studies were screened by title and abstract. Of these, 11 studies with 61 healthy participants and 177 participants diagnosed with migraine were included. Several studies reported hemodynamic effects including flushing, palpitation, warm sensation, heart rate (HR), mean arterial blood pressure (MABP), mean blood flow velocity of middle cerebral artery (mean VMCA), and diameter of superficial temporal artery (STA). Upon the start of h-α-CGRP infusion, 163 of 165 (99%) participants had flushing, 98 of 155 (63%) participants reported palpitation, and 160 of 165 (97%) participants reported warm sensation. HR increased with 14%–58% and MABP decreased with 7%–12%. The mean VMCA was decreased with 9.5%–21%, and the diameter of the STA was dilated with 41%–43%. The vascular changes lasted from 20 to >120 min. Intravenous infusion of h-α-CGRP caused a universal vasodilation without any serious adverse events. The involvement of CGRP in the systemic hemodynamic raises concerns regarding long-term blockade of CGRP in migraine patients with and without cardiovascular complications.https://www.frontiersin.org/articles/10.3389/fneur.2023.1204734/fullCalcitonin gene-related peptideinfusionhemodynamicadverse eventsheadachemigraine |
| spellingShingle | Mohammad Al-Mahdi Al-Karagholi Veberka Kalatharan Peter Schunck Fagerberg Faisal Mohammad Amin The vascular role of CGRP: a systematic review of human studies Frontiers in Neurology Calcitonin gene-related peptide infusion hemodynamic adverse events headache migraine |
| title | The vascular role of CGRP: a systematic review of human studies |
| title_full | The vascular role of CGRP: a systematic review of human studies |
| title_fullStr | The vascular role of CGRP: a systematic review of human studies |
| title_full_unstemmed | The vascular role of CGRP: a systematic review of human studies |
| title_short | The vascular role of CGRP: a systematic review of human studies |
| title_sort | vascular role of cgrp a systematic review of human studies |
| topic | Calcitonin gene-related peptide infusion hemodynamic adverse events headache migraine |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1204734/full |
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