Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9

Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9

Abstract Background Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer treatment. CRISPR/Cas9-induced mouse liver cancer models can be used to elucidate how IGH is developed. However, as CRISPR/Cas9 could induce ch...

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Bibliographic Details
Main Authors: Tao Guo, Guo-Qiao Chen, Xu-Fan Li, Meng Wang, Kun-Ming Liu, Xiao-Ying Yang, Si-Cheng Liu, Yi-Li Feng, Peng-Yuan Liu, Hui Lin, An-Yong Xie
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Genome Medicine
Subjects:
CRISPR
Cas9
Somatic multiplex-mutagenesis
Liver tumor
Intratumor genetic heterogeneity
eccDNA
Online Access:https://doi.org/10.1186/s13073-023-01230-2

Internet

https://doi.org/10.1186/s13073-023-01230-2

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