Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience
Objectives: Access and appropriateness of therapeutics for COVID-19 vary because of access or regulatory barriers, the severity of the disease, and for some therapies, the stage of the pandemic and circulating variants. Remdesivir has shown benefits in clinical recovery and is the treatment of choic...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222006488 |
| _version_ | 1828054131172966400 |
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| author | Irene Pereta Alma Morancho Néstor López Begoña Ibáñez Cristina Salas Laura Moreno Eva Castells Ariadna Barta Marta Cubedo Emmanuel Coloma Celia Cardozo Nicole García-Pouton Ainoa Ugarte Andrea Rivero Marta Bodro Verónica Rico Laura García Jordi Altés Nuria Seijas David Nicolás |
| author_facet | Irene Pereta Alma Morancho Néstor López Begoña Ibáñez Cristina Salas Laura Moreno Eva Castells Ariadna Barta Marta Cubedo Emmanuel Coloma Celia Cardozo Nicole García-Pouton Ainoa Ugarte Andrea Rivero Marta Bodro Verónica Rico Laura García Jordi Altés Nuria Seijas David Nicolás |
| author_sort | Irene Pereta |
| collection | DOAJ |
| description | Objectives: Access and appropriateness of therapeutics for COVID-19 vary because of access or regulatory barriers, the severity of the disease, and for some therapies, the stage of the pandemic and circulating variants. Remdesivir has shown benefits in clinical recovery and is the treatment of choice for selected patients, both hospitalized and nonhospitalized, in main international guidelines. The use of remdesivir in alternatives to conventional hospitalization such as hospital at home (HaH) units remains incompletely explored. In this study, we aim to describe the real-life experience of outpatient remdesivir infusion for COVID-19 in a HaH unit. Methods: We selected all the consecutive patients receiving remdesivir from a prospective cohort of 507 COVID-19 patients admitted at a HaH unit. Admission criteria included COVID-19 with a fraction of inspired oxygen requirement under 0.35 and respiratory rate under 22 rpm. Patients were daily assessed in person by a nurse and a physician. Results: A total of 236 patients admitted at the HaH unit received remdesivir, 172 of whom were treated at home. Only 2% presented any adverse event related to the infusion, all of them mild. HaH saved 1416 day-beds, with only 5% of the patients requiring transfer back to the hospital. Conclusion: Remdesivir infusion in HaH units seems to be a safe and efficient alternative to conventional hospitalization for treating patients with nonsevere COVID-19. |
| first_indexed | 2024-04-10T20:17:58Z |
| format | Article |
| id | doaj.art-97773d4a967547c8b7331b82359db025 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-10T20:17:58Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-97773d4a967547c8b7331b82359db0252023-01-26T04:44:37ZengElsevierInternational Journal of Infectious Diseases1201-97122023-02-01127124128Hospital at home treatment with remdesivir for patients with COVID-19: real-life experienceIrene Pereta0Alma Morancho1Néstor López2Begoña Ibáñez3Cristina Salas4Laura Moreno5Eva Castells6Ariadna Barta7Marta Cubedo8Emmanuel Coloma9Celia Cardozo10Nicole García-Pouton11Ainoa Ugarte12Andrea Rivero13Marta Bodro14Verónica Rico15Laura García16Jordi Altés17Nuria Seijas18David Nicolás19Hospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, SpainInternal Medicine Service, Hospital Clínic Barcelona, Barcelona, SpainInternal Medicine Service, Hospital Clínic Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, SpainNurse Direction, Hospital Clínic Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, SpainNurse Direction, Hospital Clínic Barcelona, Barcelona, SpainGenetics, Microbiology and Statistics Department, Statistics Section, Biology Faculty, Universitat de Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, Spain; Infectious Diseases Service, Hospital Clínic Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, Spain; Infectious Diseases Service, Hospital Clínic Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, Spain; Infectious Diseases Service, Hospital Clínic Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, Spain; Internal Medicine Service, Hospital Clínic Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, SpainHaematology Service, Hospital Clínic Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, Spain; Infectious Diseases Service, Hospital Clínic Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, Spain; Infectious Diseases Service, Hospital Clínic Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, SpainHospital at Home Unit, Medical and Nurse Direction, Hospital Clínic Barcelona, Barcelona, Spain; Internal Medicine Service, Hospital Clínic Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain; Corresponding author: Tel: +34-932272030/+34610560336Objectives: Access and appropriateness of therapeutics for COVID-19 vary because of access or regulatory barriers, the severity of the disease, and for some therapies, the stage of the pandemic and circulating variants. Remdesivir has shown benefits in clinical recovery and is the treatment of choice for selected patients, both hospitalized and nonhospitalized, in main international guidelines. The use of remdesivir in alternatives to conventional hospitalization such as hospital at home (HaH) units remains incompletely explored. In this study, we aim to describe the real-life experience of outpatient remdesivir infusion for COVID-19 in a HaH unit. Methods: We selected all the consecutive patients receiving remdesivir from a prospective cohort of 507 COVID-19 patients admitted at a HaH unit. Admission criteria included COVID-19 with a fraction of inspired oxygen requirement under 0.35 and respiratory rate under 22 rpm. Patients were daily assessed in person by a nurse and a physician. Results: A total of 236 patients admitted at the HaH unit received remdesivir, 172 of whom were treated at home. Only 2% presented any adverse event related to the infusion, all of them mild. HaH saved 1416 day-beds, with only 5% of the patients requiring transfer back to the hospital. Conclusion: Remdesivir infusion in HaH units seems to be a safe and efficient alternative to conventional hospitalization for treating patients with nonsevere COVID-19.http://www.sciencedirect.com/science/article/pii/S1201971222006488COVID-19RemdesivirOutpatientHospital at homeManagementOutcomes |
| spellingShingle | Irene Pereta Alma Morancho Néstor López Begoña Ibáñez Cristina Salas Laura Moreno Eva Castells Ariadna Barta Marta Cubedo Emmanuel Coloma Celia Cardozo Nicole García-Pouton Ainoa Ugarte Andrea Rivero Marta Bodro Verónica Rico Laura García Jordi Altés Nuria Seijas David Nicolás Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience International Journal of Infectious Diseases COVID-19 Remdesivir Outpatient Hospital at home Management Outcomes |
| title | Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience |
| title_full | Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience |
| title_fullStr | Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience |
| title_full_unstemmed | Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience |
| title_short | Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience |
| title_sort | hospital at home treatment with remdesivir for patients with covid 19 real life experience |
| topic | COVID-19 Remdesivir Outpatient Hospital at home Management Outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222006488 |
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