Metabolic Alterations in Sepsis
Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. Contrary to the older definitions, the current one not only focuses on inflammation, but points to systemic disturbances in homeostasis, including metabolism. Sepsis leads to sepsis-induced...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/11/2412 |
| _version_ | 1797532131636805632 |
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| author | Weronika Wasyluk Agnieszka Zwolak |
| author_facet | Weronika Wasyluk Agnieszka Zwolak |
| author_sort | Weronika Wasyluk |
| collection | DOAJ |
| description | Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. Contrary to the older definitions, the current one not only focuses on inflammation, but points to systemic disturbances in homeostasis, including metabolism. Sepsis leads to sepsis-induced dysfunction and mitochondrial damage, which is suggested as a major cause of cell metabolism disorders in these patients. The changes affect the metabolism of all macronutrients. The metabolism of all macronutrients is altered. A characteristic change in carbohydrate metabolism is the intensification of glycolysis, which in combination with the failure of entering pyruvate to the tricarboxylic acid cycle increases the formation of lactate. Sepsis also affects lipid metabolism—lipolysis in adipose tissue is upregulated, which leads to an increase in the level of fatty acids and triglycerides in the blood. At the same time, their use is disturbed, which may result in the accumulation of lipids and their toxic metabolites. Changes in the metabolism of ketone bodies and amino acids have also been described. Metabolic disorders in sepsis are an important area of research, both for their potential role as a target for future therapies (metabolic resuscitation) and for optimizing the current treatment, such as clinical nutrition. |
| first_indexed | 2024-03-10T10:54:46Z |
| format | Article |
| id | doaj.art-9777a4abeaa9492280ca6e4fb68c7fac |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T10:54:46Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9777a4abeaa9492280ca6e4fb68c7fac2023-11-21T21:59:28ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-011011241210.3390/jcm10112412Metabolic Alterations in SepsisWeronika Wasyluk0Agnieszka Zwolak1Chair of Internal Medicine and Department of Internal Medicine in Nursing, Faculty of Health Sciences, Medical University of Lublin, 20-093 Lublin, PolandChair of Internal Medicine and Department of Internal Medicine in Nursing, Faculty of Health Sciences, Medical University of Lublin, 20-093 Lublin, PolandSepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. Contrary to the older definitions, the current one not only focuses on inflammation, but points to systemic disturbances in homeostasis, including metabolism. Sepsis leads to sepsis-induced dysfunction and mitochondrial damage, which is suggested as a major cause of cell metabolism disorders in these patients. The changes affect the metabolism of all macronutrients. The metabolism of all macronutrients is altered. A characteristic change in carbohydrate metabolism is the intensification of glycolysis, which in combination with the failure of entering pyruvate to the tricarboxylic acid cycle increases the formation of lactate. Sepsis also affects lipid metabolism—lipolysis in adipose tissue is upregulated, which leads to an increase in the level of fatty acids and triglycerides in the blood. At the same time, their use is disturbed, which may result in the accumulation of lipids and their toxic metabolites. Changes in the metabolism of ketone bodies and amino acids have also been described. Metabolic disorders in sepsis are an important area of research, both for their potential role as a target for future therapies (metabolic resuscitation) and for optimizing the current treatment, such as clinical nutrition.https://www.mdpi.com/2077-0383/10/11/2412sepsisseptic shockcritical illnessintensive caremetabolismmetabolic disorders |
| spellingShingle | Weronika Wasyluk Agnieszka Zwolak Metabolic Alterations in Sepsis Journal of Clinical Medicine sepsis septic shock critical illness intensive care metabolism metabolic disorders |
| title | Metabolic Alterations in Sepsis |
| title_full | Metabolic Alterations in Sepsis |
| title_fullStr | Metabolic Alterations in Sepsis |
| title_full_unstemmed | Metabolic Alterations in Sepsis |
| title_short | Metabolic Alterations in Sepsis |
| title_sort | metabolic alterations in sepsis |
| topic | sepsis septic shock critical illness intensive care metabolism metabolic disorders |
| url | https://www.mdpi.com/2077-0383/10/11/2412 |
| work_keys_str_mv | AT weronikawasyluk metabolicalterationsinsepsis AT agnieszkazwolak metabolicalterationsinsepsis |