Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often characterized by a life-threatening interstitial pneumonia requiring hospitalization. The aim of this retrospective cohort study is to identify hallmarks of in-hospital mortality in patients affected by Coronavirus Disease 19 (COV...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/322 |
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| author | Diana Fuzio Angelo Michele Inchingolo Vitalba Ruggieri Massimo Fasano Maria Federico Manuela Mandorino Lavinia Dirienzo Salvatore Scacco Alessandro Rizzello Maurizio Delvecchio Massimiliano Parise Roberto Rana Nicola Faccilongo Biagio Rapone Francesco Inchingolo Antonio Mancini Maria Celeste Fatone Antonio Gnoni Gianna Dipalma Giovanni Dirienzo |
| author_facet | Diana Fuzio Angelo Michele Inchingolo Vitalba Ruggieri Massimo Fasano Maria Federico Manuela Mandorino Lavinia Dirienzo Salvatore Scacco Alessandro Rizzello Maurizio Delvecchio Massimiliano Parise Roberto Rana Nicola Faccilongo Biagio Rapone Francesco Inchingolo Antonio Mancini Maria Celeste Fatone Antonio Gnoni Gianna Dipalma Giovanni Dirienzo |
| author_sort | Diana Fuzio |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often characterized by a life-threatening interstitial pneumonia requiring hospitalization. The aim of this retrospective cohort study is to identify hallmarks of in-hospital mortality in patients affected by Coronavirus Disease 19 (COVID-19). A total of 150 patients admitted for COVID-19 from March to June 2021 to “F. Perinei” Murgia Hospital in Altamura, Italy, were divided into survivors (<i>n</i> = 100) and non-survivors groups (<i>n</i> = 50). Blood counts, inflammation-related biomarkers and lymphocyte subsets were analyzed into two groups in the first 24 h after admission and compared by Student’s t-test. A multivariable logistic analysis was performed to identify independent risk factors associated with in-hospital mortality. Total lymphocyte count and CD3<sup>+</sup> and CD4<sup>+</sup> CD8<sup>+</sup> T lymphocyte subsets were significantly lower in non-survivors. Serum levels of interleukin-6 (IL-6), lactate dehydrogenase (LDH), C-reactive protein (CRP) and procalcitonin (PCT) were significantly higher in non-survivors. Age > 65 years and presence of comorbidities were identified as independent risk factors associated with in-hospital mortality, while IL-6 and LDH showed a borderline significance. According to our results, markers of inflammation and lymphocytopenia predict in-hospital mortality in COVID-19. |
| first_indexed | 2024-03-11T08:33:46Z |
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| id | doaj.art-9777cf0274714a09a648d9933ba67212 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:33:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-9777cf0274714a09a648d9933ba672122023-11-16T21:39:40ZengMDPI AGLife2075-17292023-01-0113232210.3390/life13020322Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 InfectionDiana Fuzio0Angelo Michele Inchingolo1Vitalba Ruggieri2Massimo Fasano3Maria Federico4Manuela Mandorino5Lavinia Dirienzo6Salvatore Scacco7Alessandro Rizzello8Maurizio Delvecchio9Massimiliano Parise10Roberto Rana11Nicola Faccilongo12Biagio Rapone13Francesco Inchingolo14Antonio Mancini15Maria Celeste Fatone16Antonio Gnoni17Gianna Dipalma18Giovanni Dirienzo19Clinical Pathology Unit, Murgia Hospital, Asl Bari, 70022 Altamura, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyClinical Pathology Unit, Murgia Hospital, Asl Bari, 70022 Altamura, ItalyInfectious Diseases Complex Unit, Murgia Hospital, Asl Bari, 70022 Altamura, ItalyInfectious Diseases Complex Unit, Murgia Hospital, Asl Bari, 70022 Altamura, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyUniversitary Clinical Pathology Complex Unit, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, ItalyMetabolic Disorders and Diabetes Unit, “Giovanni XXIII” Children’s Hospital, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Economics, University of Foggia, 71100 Foggia, ItalyDepartment of Economics, University of Foggia, 71100 Foggia, ItalyDepartment of Economics, University of Foggia, 71100 Foggia, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyPTA Trani, ASL BT, Internal Medicine Surgery, Viale Padre Pio, 76125 Trani, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyClinical Pathology Unit, Murgia Hospital, Asl Bari, 70022 Altamura, ItalySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often characterized by a life-threatening interstitial pneumonia requiring hospitalization. The aim of this retrospective cohort study is to identify hallmarks of in-hospital mortality in patients affected by Coronavirus Disease 19 (COVID-19). A total of 150 patients admitted for COVID-19 from March to June 2021 to “F. Perinei” Murgia Hospital in Altamura, Italy, were divided into survivors (<i>n</i> = 100) and non-survivors groups (<i>n</i> = 50). Blood counts, inflammation-related biomarkers and lymphocyte subsets were analyzed into two groups in the first 24 h after admission and compared by Student’s t-test. A multivariable logistic analysis was performed to identify independent risk factors associated with in-hospital mortality. Total lymphocyte count and CD3<sup>+</sup> and CD4<sup>+</sup> CD8<sup>+</sup> T lymphocyte subsets were significantly lower in non-survivors. Serum levels of interleukin-6 (IL-6), lactate dehydrogenase (LDH), C-reactive protein (CRP) and procalcitonin (PCT) were significantly higher in non-survivors. Age > 65 years and presence of comorbidities were identified as independent risk factors associated with in-hospital mortality, while IL-6 and LDH showed a borderline significance. According to our results, markers of inflammation and lymphocytopenia predict in-hospital mortality in COVID-19.https://www.mdpi.com/2075-1729/13/2/322biomarkersCOVID-19C-reactive proteininterleukin-6inflammationin-hospital mortality |
| spellingShingle | Diana Fuzio Angelo Michele Inchingolo Vitalba Ruggieri Massimo Fasano Maria Federico Manuela Mandorino Lavinia Dirienzo Salvatore Scacco Alessandro Rizzello Maurizio Delvecchio Massimiliano Parise Roberto Rana Nicola Faccilongo Biagio Rapone Francesco Inchingolo Antonio Mancini Maria Celeste Fatone Antonio Gnoni Gianna Dipalma Giovanni Dirienzo Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection Life biomarkers COVID-19 C-reactive protein interleukin-6 inflammation in-hospital mortality |
| title | Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection |
| title_full | Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection |
| title_fullStr | Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection |
| title_full_unstemmed | Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection |
| title_short | Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection |
| title_sort | inflammation as prognostic hallmark of clinical outcome in patients with sars cov 2 infection |
| topic | biomarkers COVID-19 C-reactive protein interleukin-6 inflammation in-hospital mortality |
| url | https://www.mdpi.com/2075-1729/13/2/322 |
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