The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation
Quantitative flow ratio (QFR) is a new method for the assessment of the extent of coronary artery stenosis. But it may be obscured by the cardiac remodeling and abnormal blood flow of the coronary artery when encountering atrial fibrillation (AF). The present study aimed to examine the impact of the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi-Wiley
2023-01-01
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| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2023/7278343 |
| _version_ | 1797654038322348032 |
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| author | Wenbin Lu Xiaoguo Zhang Gaoliang Yan Genshan Ma |
| author_facet | Wenbin Lu Xiaoguo Zhang Gaoliang Yan Genshan Ma |
| author_sort | Wenbin Lu |
| collection | DOAJ |
| description | Quantitative flow ratio (QFR) is a new method for the assessment of the extent of coronary artery stenosis. But it may be obscured by the cardiac remodeling and abnormal blood flow of the coronary artery when encountering atrial fibrillation (AF). The present study aimed to examine the impact of these changed structures and blood flow of coronary arteries on QFR results in AF patients. Methods and Results. We evaluated QFR in 223 patients (112 patients with AF; 111 non-AF patients served as controls) who had undergone percutaneous coronary intervention (PCI) due to severe stenoses in coronary arteries. QFR of the target coronary was determined according to the flow rate of the contrast agent. Results showed that AF patients had significantly higher QFR values than control (0.792 ± 0.118 vs. 0.685 ± 0.167, p<0.001). We further analyzed local QFR around the stenoses (0.858 ± 0.304 vs. 0.756 ± 0.146, p=0.002), residual QFR (0.958 ± 0.055 vs. 0.929 ± 0.093, p=0.005), and index QFR (0.807 ± 0.108 vs. 0.713 ± 0.152, p<0.001) in these two groups of patients with and without AF. Further analysis revealed that QFR in AF patients was negatively correlated with coronary flow velocity (R = −0.22, p=0.02) and area of stenosis (R = −0.70, p<0.001) but positively correlated with the minimum lumen area (MLA) (R = 0.47, p<0.001). Conclusion. AF patients with coronary artery stenosis have higher QFR values, which are associated with decreased blood flow velocity, smaller stenosis, and larger MLA in AF patients upon cardiac remodeling. |
| first_indexed | 2024-03-11T16:52:33Z |
| format | Article |
| id | doaj.art-97784c3b5e904c009d395e2aa5a2ed90 |
| institution | Directory Open Access Journal |
| issn | 1540-8183 |
| language | English |
| last_indexed | 2024-03-11T16:52:33Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi-Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj.art-97784c3b5e904c009d395e2aa5a2ed902023-10-21T00:00:02ZengHindawi-WileyJournal of Interventional Cardiology1540-81832023-01-01202310.1155/2023/7278343The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial FibrillationWenbin Lu0Xiaoguo Zhang1Gaoliang Yan2Genshan Ma3Department of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyQuantitative flow ratio (QFR) is a new method for the assessment of the extent of coronary artery stenosis. But it may be obscured by the cardiac remodeling and abnormal blood flow of the coronary artery when encountering atrial fibrillation (AF). The present study aimed to examine the impact of these changed structures and blood flow of coronary arteries on QFR results in AF patients. Methods and Results. We evaluated QFR in 223 patients (112 patients with AF; 111 non-AF patients served as controls) who had undergone percutaneous coronary intervention (PCI) due to severe stenoses in coronary arteries. QFR of the target coronary was determined according to the flow rate of the contrast agent. Results showed that AF patients had significantly higher QFR values than control (0.792 ± 0.118 vs. 0.685 ± 0.167, p<0.001). We further analyzed local QFR around the stenoses (0.858 ± 0.304 vs. 0.756 ± 0.146, p=0.002), residual QFR (0.958 ± 0.055 vs. 0.929 ± 0.093, p=0.005), and index QFR (0.807 ± 0.108 vs. 0.713 ± 0.152, p<0.001) in these two groups of patients with and without AF. Further analysis revealed that QFR in AF patients was negatively correlated with coronary flow velocity (R = −0.22, p=0.02) and area of stenosis (R = −0.70, p<0.001) but positively correlated with the minimum lumen area (MLA) (R = 0.47, p<0.001). Conclusion. AF patients with coronary artery stenosis have higher QFR values, which are associated with decreased blood flow velocity, smaller stenosis, and larger MLA in AF patients upon cardiac remodeling.http://dx.doi.org/10.1155/2023/7278343 |
| spellingShingle | Wenbin Lu Xiaoguo Zhang Gaoliang Yan Genshan Ma The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation Journal of Interventional Cardiology |
| title | The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation |
| title_full | The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation |
| title_fullStr | The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation |
| title_full_unstemmed | The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation |
| title_short | The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation |
| title_sort | differences of quantitative flow ratio in coronary artery stenosis with or without atrial fibrillation |
| url | http://dx.doi.org/10.1155/2023/7278343 |
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