Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
Aim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF). Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into tw...
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| Format: | Article |
| Language: | English |
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Concilium Medicum
2021-02-01
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| Series: | КардиоСоматика |
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| Online Access: | https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/60807/43924 |
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| author | Vitalii G. Tregubov Pavel V. Khil′kevich Iosif Z. Shubitidze Anna V. Tregubova |
| author_facet | Vitalii G. Tregubov Pavel V. Khil′kevich Iosif Z. Shubitidze Anna V. Tregubova |
| author_sort | Vitalii G. Tregubov |
| collection | DOAJ |
| description | Aim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF).
Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into two groups for treatment with bisoprolol or carvedilol. As part of the combination therapy was prescribed quinapril, and if indicated atorvastatin, acetylsalicylic acid in the intestinal soluble shell. Initially and after 24 weeks of therapy were carried out: quantitative assessment of regulatory-adaptive status (RAS), echocardioscopy, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of level of N-terminal fragment of the brain natriuretic peptide precursor in blood plasma.
Results. Both schemes of combined therapy comparably improved the morpho-functional parameters of the heart and quality of life. In comparison with carvedilol, nebivolol more pronouncedly increased RAS and tolerance to physical activity.
Conclusion. In patients with diastolic CHF in combination therapy, the use of nebivolol, in comparison with carvedilol, may be preferable due to the positive effect on the functional state. |
| first_indexed | 2024-12-14T08:13:23Z |
| format | Article |
| id | doaj.art-97784ce1d6f444d1b8d37ea9d1c511a2 |
| institution | Directory Open Access Journal |
| issn | 2221-7185 2658-5707 |
| language | English |
| last_indexed | 2024-12-14T08:13:23Z |
| publishDate | 2021-02-01 |
| publisher | Concilium Medicum |
| record_format | Article |
| series | КардиоСоматика |
| spelling | doaj.art-97784ce1d6f444d1b8d37ea9d1c511a22022-12-21T23:10:01ZengConcilium MedicumКардиоСоматика2221-71852658-57072021-02-01114252910.26442/22217185.2020.4.20056555678Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failureVitalii G. Tregubov0Pavel V. Khil′kevich1Iosif Z. Shubitidze2Anna V. Tregubova3Kuban State Medical UniversityKuban State Medical UniversityRegional Clinical Hospital №2Kuban State Medical UniversityAim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF). Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into two groups for treatment with bisoprolol or carvedilol. As part of the combination therapy was prescribed quinapril, and if indicated atorvastatin, acetylsalicylic acid in the intestinal soluble shell. Initially and after 24 weeks of therapy were carried out: quantitative assessment of regulatory-adaptive status (RAS), echocardioscopy, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of level of N-terminal fragment of the brain natriuretic peptide precursor in blood plasma. Results. Both schemes of combined therapy comparably improved the morpho-functional parameters of the heart and quality of life. In comparison with carvedilol, nebivolol more pronouncedly increased RAS and tolerance to physical activity. Conclusion. In patients with diastolic CHF in combination therapy, the use of nebivolol, in comparison with carvedilol, may be preferable due to the positive effect on the functional state.https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/60807/43924chronic heart failurenebivololcarvedilolfunctional stateregulatory-adaptive status |
| spellingShingle | Vitalii G. Tregubov Pavel V. Khil′kevich Iosif Z. Shubitidze Anna V. Tregubova Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure КардиоСоматика chronic heart failure nebivolol carvedilol functional state regulatory-adaptive status |
| title | Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure |
| title_full | Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure |
| title_fullStr | Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure |
| title_full_unstemmed | Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure |
| title_short | Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure |
| title_sort | assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure |
| topic | chronic heart failure nebivolol carvedilol functional state regulatory-adaptive status |
| url | https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/60807/43924 |
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