Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/11/6047 |
| _version_ | 1797493178017775616 |
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| author | Tsai-Chin Cheng Shou-Hsien Huang Chung-Lan Kao Po-Cheng Hsu |
| author_facet | Tsai-Chin Cheng Shou-Hsien Huang Chung-Lan Kao Po-Cheng Hsu |
| author_sort | Tsai-Chin Cheng |
| collection | DOAJ |
| description | Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin-like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA- and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology. |
| first_indexed | 2024-03-10T01:16:17Z |
| format | Article |
| id | doaj.art-977a37d67de14ed2840eca88ee22280b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:16:17Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-977a37d67de14ed2840eca88ee22280b2023-11-23T14:08:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012311604710.3390/ijms23116047Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative ReviewTsai-Chin Cheng0Shou-Hsien Huang1Chung-Lan Kao2Po-Cheng Hsu3Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei 112, TaiwanDepartment of Physical Medicine and Rehabilitation, Far Eastern Memorial Hospital, New Taipei City 220, TaiwanDepartment of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei 112, TaiwanDepartment of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei 112, TaiwanMuscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin-like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA- and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology.https://www.mdpi.com/1422-0067/23/11/6047chronic kidney diseasemuscle wastingmolecular mechanismprotein metabolismmuscle regenerationexercise |
| spellingShingle | Tsai-Chin Cheng Shou-Hsien Huang Chung-Lan Kao Po-Cheng Hsu Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review International Journal of Molecular Sciences chronic kidney disease muscle wasting molecular mechanism protein metabolism muscle regeneration exercise |
| title | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
| title_full | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
| title_fullStr | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
| title_full_unstemmed | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
| title_short | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
| title_sort | muscle wasting in chronic kidney disease mechanism and clinical implications a narrative review |
| topic | chronic kidney disease muscle wasting molecular mechanism protein metabolism muscle regeneration exercise |
| url | https://www.mdpi.com/1422-0067/23/11/6047 |
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