The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations
The successful introduction of innovative treatment strategies into clinical practise strongly depends on the availability of effective experimental models and their reliable pre-clinical assessment. Considering pre-clinical research for peripheral nerve repair and reconstruction, the far most used...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00288/full |
| _version_ | 1818025581985398784 |
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| author | Giulia Ronchi Giulia Ronchi Michela Morano Michela Morano Federica Fregnan Federica Fregnan Pierfrancesco Pugliese Alessandro Crosio Pierluigi Tos Stefano Geuna Stefano Geuna Kirsten Haastert-Talini Kirsten Haastert-Talini Giovanna Gambarotta |
| author_facet | Giulia Ronchi Giulia Ronchi Michela Morano Michela Morano Federica Fregnan Federica Fregnan Pierfrancesco Pugliese Alessandro Crosio Pierluigi Tos Stefano Geuna Stefano Geuna Kirsten Haastert-Talini Kirsten Haastert-Talini Giovanna Gambarotta |
| author_sort | Giulia Ronchi |
| collection | DOAJ |
| description | The successful introduction of innovative treatment strategies into clinical practise strongly depends on the availability of effective experimental models and their reliable pre-clinical assessment. Considering pre-clinical research for peripheral nerve repair and reconstruction, the far most used nerve regeneration model in the last decades is the sciatic nerve injury and repair model. More recently, the use of the median nerve injury and repair model has gained increasing attention due to some significant advantages it provides compared to sciatic nerve injury. Outstanding advantages are the availability of reliable behavioural tests for assessing posttraumatic voluntary motor recovery and a much lower impact on the animal wellbeing. In this article, the potential application of the median nerve injury and repair model in pre-clinical research is reviewed. In addition, we provide a synthetic overview of a variety of methods that can be applied in this model for nerve regeneration assessment. This article is aimed at helping researchers in adequately adopting this in vivo model for pre-clinical evaluation of peripheral nerve reconstruction as well as for interpreting the results in a translational perspective. |
| first_indexed | 2024-12-10T04:18:24Z |
| format | Article |
| id | doaj.art-977a641a68eb43da8b170b73f5d93bff |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T04:18:24Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-977a641a68eb43da8b170b73f5d93bff2022-12-22T02:02:30ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-06-011310.3389/fncel.2019.00288447038The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and LimitationsGiulia Ronchi0Giulia Ronchi1Michela Morano2Michela Morano3Federica Fregnan4Federica Fregnan5Pierfrancesco Pugliese6Alessandro Crosio7Pierluigi Tos8Stefano Geuna9Stefano Geuna10Kirsten Haastert-Talini11Kirsten Haastert-Talini12Giovanna Gambarotta13Department of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi Foundation (NICO), University of Turin, Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi Foundation (NICO), University of Turin, Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi Foundation (NICO), University of Turin, Turin, ItalyDipartimento di Chirurgia Generale e Specialistica, Azienda Ospedaliera Universitaria, Ancona, ItalyUO Microchirurgia e Chirurgia della Mano, Ospedale Gaetano Pini, Milan, ItalyUO Microchirurgia e Chirurgia della Mano, Ospedale Gaetano Pini, Milan, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi Foundation (NICO), University of Turin, Turin, ItalyInstitute of Neuroanatomy and Cell Biology, Hannover Medical School, Hanover, GermanyCenter for Systems Neuroscience (ZSN) Hannover, Hanover, GermanyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyThe successful introduction of innovative treatment strategies into clinical practise strongly depends on the availability of effective experimental models and their reliable pre-clinical assessment. Considering pre-clinical research for peripheral nerve repair and reconstruction, the far most used nerve regeneration model in the last decades is the sciatic nerve injury and repair model. More recently, the use of the median nerve injury and repair model has gained increasing attention due to some significant advantages it provides compared to sciatic nerve injury. Outstanding advantages are the availability of reliable behavioural tests for assessing posttraumatic voluntary motor recovery and a much lower impact on the animal wellbeing. In this article, the potential application of the median nerve injury and repair model in pre-clinical research is reviewed. In addition, we provide a synthetic overview of a variety of methods that can be applied in this model for nerve regeneration assessment. This article is aimed at helping researchers in adequately adopting this in vivo model for pre-clinical evaluation of peripheral nerve reconstruction as well as for interpreting the results in a translational perspective.https://www.frontiersin.org/article/10.3389/fncel.2019.00288/fullmedian nerveinjuryanimal experimental modelrepairregenerationtranslational research |
| spellingShingle | Giulia Ronchi Giulia Ronchi Michela Morano Michela Morano Federica Fregnan Federica Fregnan Pierfrancesco Pugliese Alessandro Crosio Pierluigi Tos Stefano Geuna Stefano Geuna Kirsten Haastert-Talini Kirsten Haastert-Talini Giovanna Gambarotta The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations Frontiers in Cellular Neuroscience median nerve injury animal experimental model repair regeneration translational research |
| title | The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations |
| title_full | The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations |
| title_fullStr | The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations |
| title_full_unstemmed | The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations |
| title_short | The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations |
| title_sort | median nerve injury model in pre clinical research a critical review on benefits and limitations |
| topic | median nerve injury animal experimental model repair regeneration translational research |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00288/full |
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