A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia
Background: Although endocrine disorders are not a common cause of infertility, in some cases, testing thyroid function, and hypothalamus - pituitary - gonadal axis can determine the cause of infertility. We aimed to investigate the effect of the aerial parts of Alhagi camelorum extract on prolactin...
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| Format: | Article |
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PAGEPress Publications
2014-09-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | http://www.pagepressjournals.org/index.php/aiua/article/view/4753 |
| _version_ | 1818307069873225728 |
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| author | Ali Zarei Saeed Changizi Ashtiyani Gholam Hassan Vaezi |
| author_facet | Ali Zarei Saeed Changizi Ashtiyani Gholam Hassan Vaezi |
| author_sort | Ali Zarei |
| collection | DOAJ |
| description | Background: Although endocrine disorders are not a common cause of infertility, in some cases, testing thyroid function, and hypothalamus - pituitary - gonadal axis can determine the cause of infertility. We aimed to investigate the effect of the aerial parts of Alhagi camelorum extract on prolactin, cortisol and pituitary - gonadal axis activities in rats with hypercholesterolemia. Materials and methods: In this study, 35 male wistar rats in 5 groups (n = 7) were assigned as: control group with normal diet, the sham group with fat diet and three experimental groups of hypercholesterolaemic animals which received Alhagi camelorum extract at a minimum dose of 100 mg/kg, average dose of 200 ml/kg and maximum dose of 300 mg/kg over a period of 21 days. At the end of the period, blood samples were collected from all groups and blood factors were then measured and analyzed. Results: In the sham group compared to the control, cholesterol levels increased and FSH levels decreased, whereas cholesterol levels reduced in the experimental groups. Alhagi camelorum extract also reduced testosterone level and increased prolactin and gonadotropins. Conclusion: Alhagi camelorum extract at low and average doses reduced cortisol, testosterone and cholesterol and increased gonadotropins. So it can cause reproductive disorders in male rats. The extract at maximum dose can increase cortisol and prolactin. As these two hormones work together to produce milk, this plant can help to boost breastfeeding. |
| first_indexed | 2024-12-13T06:52:31Z |
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| id | doaj.art-977b3ec4755d411e8649d12efa82dfef |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-12-13T06:52:31Z |
| publishDate | 2014-09-01 |
| publisher | PAGEPress Publications |
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| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-977b3ec4755d411e8649d12efa82dfef2022-12-21T23:56:07ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972014-09-0186318819210.4081/aiua.2014.3.1883903A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemiaAli Zarei0Saeed Changizi Ashtiyani1Gholam Hassan Vaezi2Young Researchers Club, Abadeh Branch, Islamic Azad University, AbadehDepartment of Physiology, Arak University of Medical Sciences, Arak, IranDepartment of biology, Islamic Azad University, Damghan Branch, SemnanBackground: Although endocrine disorders are not a common cause of infertility, in some cases, testing thyroid function, and hypothalamus - pituitary - gonadal axis can determine the cause of infertility. We aimed to investigate the effect of the aerial parts of Alhagi camelorum extract on prolactin, cortisol and pituitary - gonadal axis activities in rats with hypercholesterolemia. Materials and methods: In this study, 35 male wistar rats in 5 groups (n = 7) were assigned as: control group with normal diet, the sham group with fat diet and three experimental groups of hypercholesterolaemic animals which received Alhagi camelorum extract at a minimum dose of 100 mg/kg, average dose of 200 ml/kg and maximum dose of 300 mg/kg over a period of 21 days. At the end of the period, blood samples were collected from all groups and blood factors were then measured and analyzed. Results: In the sham group compared to the control, cholesterol levels increased and FSH levels decreased, whereas cholesterol levels reduced in the experimental groups. Alhagi camelorum extract also reduced testosterone level and increased prolactin and gonadotropins. Conclusion: Alhagi camelorum extract at low and average doses reduced cortisol, testosterone and cholesterol and increased gonadotropins. So it can cause reproductive disorders in male rats. The extract at maximum dose can increase cortisol and prolactin. As these two hormones work together to produce milk, this plant can help to boost breastfeeding.http://www.pagepressjournals.org/index.php/aiua/article/view/4753Alhagi camelorumProlactinTestosteroneCholesterolGonadotropin |
| spellingShingle | Ali Zarei Saeed Changizi Ashtiyani Gholam Hassan Vaezi A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia Archivio Italiano di Urologia e Andrologia Alhagi camelorum Prolactin Testosterone Cholesterol Gonadotropin |
| title | A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia |
| title_full | A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia |
| title_fullStr | A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia |
| title_full_unstemmed | A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia |
| title_short | A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia |
| title_sort | study on the effects of the hydroalcholic extract of the aerial parts of alhagi camelorum on prolactin and pituitary gonadal activity in rats with hypercholesterolemia |
| topic | Alhagi camelorum Prolactin Testosterone Cholesterol Gonadotropin |
| url | http://www.pagepressjournals.org/index.php/aiua/article/view/4753 |
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