Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes
Abstract Background Overlapping genes share same genomic regions in parallel (sense) or anti-parallel (anti-sense) orientations. These gene pairs seem to occur in all domains of life and are best known from viruses. However, the advantage and biological significance of overlapping genes is still unc...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-10-01
|
| Series: | BMC Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12864-021-08039-6 |
| _version_ | 1818695274115104768 |
|---|---|
| author | Majid Mehravar Fatemeh Ghaemimanesh Ensieh M. Poursani |
| author_facet | Majid Mehravar Fatemeh Ghaemimanesh Ensieh M. Poursani |
| author_sort | Majid Mehravar |
| collection | DOAJ |
| description | Abstract Background Overlapping genes share same genomic regions in parallel (sense) or anti-parallel (anti-sense) orientations. These gene pairs seem to occur in all domains of life and are best known from viruses. However, the advantage and biological significance of overlapping genes is still unclear. Expressed sequence tags (ESTs) analysis enabled us to uncover an overlapping gene pair in the human genome. Results By using in silico analysis of previous experimental documentations, we reveal a new form of overlapping genes in the human genome, in which two genes found on opposite strands (Pou5f1 and Tcf19), share two exons and one intron enclosed, at the same positions, between OCT4B3 and TCF19-D splice variants. Conclusions This new form of overlapping gene expands our previous perception of splicing events and may shed more light on the complexity of gene regulation in higher organisms. Additional such genes might be detected by ESTs analysis also of other organisms. |
| first_indexed | 2024-12-17T13:42:52Z |
| format | Article |
| id | doaj.art-977b74fb00a54c04937644439cdd0675 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-17T13:42:52Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-977b74fb00a54c04937644439cdd06752022-12-21T21:46:14ZengBMCBMC Genomics1471-21642021-10-012211710.1186/s12864-021-08039-6Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genesMajid Mehravar0Fatemeh Ghaemimanesh1Ensieh M. Poursani2Department of Anatomy and Developmental Biology, Development and Stem Cells Program, Biomedicine Discovery Institute, Monash UniversityMonoclonal Antibody Research Center, Avicenna Research Institute, ACECRHematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesAbstract Background Overlapping genes share same genomic regions in parallel (sense) or anti-parallel (anti-sense) orientations. These gene pairs seem to occur in all domains of life and are best known from viruses. However, the advantage and biological significance of overlapping genes is still unclear. Expressed sequence tags (ESTs) analysis enabled us to uncover an overlapping gene pair in the human genome. Results By using in silico analysis of previous experimental documentations, we reveal a new form of overlapping genes in the human genome, in which two genes found on opposite strands (Pou5f1 and Tcf19), share two exons and one intron enclosed, at the same positions, between OCT4B3 and TCF19-D splice variants. Conclusions This new form of overlapping gene expands our previous perception of splicing events and may shed more light on the complexity of gene regulation in higher organisms. Additional such genes might be detected by ESTs analysis also of other organisms.https://doi.org/10.1186/s12864-021-08039-6Overlapping genesExon sharingIntron sharingPouf51OCT4, Tcf19 |
| spellingShingle | Majid Mehravar Fatemeh Ghaemimanesh Ensieh M. Poursani Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes BMC Genomics Overlapping genes Exon sharing Intron sharing Pouf51 OCT4, Tcf19 |
| title | Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes |
| title_full | Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes |
| title_fullStr | Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes |
| title_full_unstemmed | Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes |
| title_short | Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes |
| title_sort | exon and intron sharing in opposite direction an undocumented phenomenon in human genome between pou5f1 and tcf19 genes |
| topic | Overlapping genes Exon sharing Intron sharing Pouf51 OCT4, Tcf19 |
| url | https://doi.org/10.1186/s12864-021-08039-6 |
| work_keys_str_mv | AT majidmehravar exonandintronsharinginoppositedirectionanundocumentedphenomenoninhumangenomebetweenpou5f1andtcf19genes AT fatemehghaemimanesh exonandintronsharinginoppositedirectionanundocumentedphenomenoninhumangenomebetweenpou5f1andtcf19genes AT ensiehmpoursani exonandintronsharinginoppositedirectionanundocumentedphenomenoninhumangenomebetweenpou5f1andtcf19genes |