Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts.

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts.

The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a chronic infection which is fatal when untreated. Herein, we investigated whether in addition to altering transcription, L. donovani modulates host mRNA translation to establish a successful infection. Polysome-...

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Bibliographic Details
Main Authors: Visnu Chaparro, Louis-Philippe Leroux, Laia Masvidal, Julie Lorent, Tyson E Graber, Aude Zimmermann, Guillermo Arango Duque, Albert Descoteaux, Tommy Alain, Ola Larsson, Maritza Jaramillo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008291

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