A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil
Background: Rapidly growing mycobacteria (RGM) are a group of nontuberculous mycobacteria (NTM) implicated in difficult-to-treat pulmonary and extrapulmonary diseases, possibly associated with invasive procedures and failures in sterilization of materials and equipment. Methods: We report our experi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | International Journal of Mycobacteriology |
| Subjects: | |
| Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2021;volume=10;issue=2;spage=170;epage=176;aulast=Silveira |
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| author | Heloisa da Silveira Paro Pedro Susilene Maria Tonelli Nardi Naiara Cristina Ule Belotti Ana Carolina Tegon de Freitas Nilza Gomes de Souza Erica Chimara |
| author_facet | Heloisa da Silveira Paro Pedro Susilene Maria Tonelli Nardi Naiara Cristina Ule Belotti Ana Carolina Tegon de Freitas Nilza Gomes de Souza Erica Chimara |
| author_sort | Heloisa da Silveira Paro Pedro |
| collection | DOAJ |
| description | Background: Rapidly growing mycobacteria (RGM) are a group of nontuberculous mycobacteria (NTM) implicated in difficult-to-treat pulmonary and extrapulmonary diseases, possibly associated with invasive procedures and failures in sterilization of materials and equipment. Methods: We report our experience with the laboratory identification of RGM in a routine work and give an overview of the RGM isolated in our setting. Laboratorial data from all RGM mycobacterial isolates received at Adolfo Lutz Institute of São José do Rio Preto were analyzed from January 2000 to December 2015. Results: Five hundred and seventy-nine isolates were identified with NTM, of which 193 were RGM, which affected 113 patients. Among the 113 patients, the female gender was more frequent (55%) and the average age was 50 years. Pulmonary samples were the most frequent (79%), and 54.9% of the cases were isolated from sputum. Twelve different species were found and the most identified were group Mycobacterium abscessus and Mycobacterium fortuitum, making up 77.9% of all identified RGM. The most frequent comorbidities were smoking (n = 21), alcoholism (n = 12), and human immunodeficiency virus (n = 16). Drug susceptibility test was performed for nine patients and all showed susceptibility to amikacin and seven resistances to doxycycline. Conclusions: This study showed the experience of mycobacterial diagnosis in a routine laboratory, revealing that failure to meet the bacteriological criteria generates losses in the establishment of cases of RGM and consequently its correct treatment. |
| first_indexed | 2024-12-21T07:36:33Z |
| format | Article |
| id | doaj.art-977de6a159c140cea38fe3a94e1a696e |
| institution | Directory Open Access Journal |
| issn | 2212-5531 2212-554X |
| language | English |
| last_indexed | 2024-12-21T07:36:33Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj.art-977de6a159c140cea38fe3a94e1a696e2022-12-21T19:11:27ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2021-01-0110217017610.4103/ijmy.ijmy_65_21A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, BrazilHeloisa da Silveira Paro PedroSusilene Maria Tonelli NardiNaiara Cristina Ule BelottiAna Carolina Tegon de FreitasNilza Gomes de SouzaErica ChimaraBackground: Rapidly growing mycobacteria (RGM) are a group of nontuberculous mycobacteria (NTM) implicated in difficult-to-treat pulmonary and extrapulmonary diseases, possibly associated with invasive procedures and failures in sterilization of materials and equipment. Methods: We report our experience with the laboratory identification of RGM in a routine work and give an overview of the RGM isolated in our setting. Laboratorial data from all RGM mycobacterial isolates received at Adolfo Lutz Institute of São José do Rio Preto were analyzed from January 2000 to December 2015. Results: Five hundred and seventy-nine isolates were identified with NTM, of which 193 were RGM, which affected 113 patients. Among the 113 patients, the female gender was more frequent (55%) and the average age was 50 years. Pulmonary samples were the most frequent (79%), and 54.9% of the cases were isolated from sputum. Twelve different species were found and the most identified were group Mycobacterium abscessus and Mycobacterium fortuitum, making up 77.9% of all identified RGM. The most frequent comorbidities were smoking (n = 21), alcoholism (n = 12), and human immunodeficiency virus (n = 16). Drug susceptibility test was performed for nine patients and all showed susceptibility to amikacin and seven resistances to doxycycline. Conclusions: This study showed the experience of mycobacterial diagnosis in a routine laboratory, revealing that failure to meet the bacteriological criteria generates losses in the establishment of cases of RGM and consequently its correct treatment.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2021;volume=10;issue=2;spage=170;epage=176;aulast=Silveiramycobacterium abscessusmycobacterium fortuitumrapidly growing mycobacteria |
| spellingShingle | Heloisa da Silveira Paro Pedro Susilene Maria Tonelli Nardi Naiara Cristina Ule Belotti Ana Carolina Tegon de Freitas Nilza Gomes de Souza Erica Chimara A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil International Journal of Mycobacteriology mycobacterium abscessus mycobacterium fortuitum rapidly growing mycobacteria |
| title | A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil |
| title_full | A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil |
| title_fullStr | A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil |
| title_full_unstemmed | A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil |
| title_short | A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil |
| title_sort | laboratory based analysis of rapidly growing mycobacteria in northwest paulista sao paulo brazil |
| topic | mycobacterium abscessus mycobacterium fortuitum rapidly growing mycobacteria |
| url | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2021;volume=10;issue=2;spage=170;epage=176;aulast=Silveira |
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