The Role of Nuclear Bodies in Gene Expression and Disease
This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, his...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-07-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/2/3/976 |
| _version_ | 1827885546327769088 |
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| author | Marie Morimoto Cornelius F. Boerkoel |
| author_facet | Marie Morimoto Cornelius F. Boerkoel |
| author_sort | Marie Morimoto |
| collection | DOAJ |
| description | This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, histone gene synthesis and nuclear RNA retention, has significant implications for gene regulation. These functional nuclear domains include the nucleolus, nuclear speckle, nuclear stress body, transcription factory, Cajal body, Gemini of Cajal body, histone locus body and paraspeckle. We herein review the roles of nuclear bodies in regulating gene expression and their relation to human health and disease. |
| first_indexed | 2024-03-12T19:47:22Z |
| format | Article |
| id | doaj.art-977ef6ed0b2c46e6ad768ffd82594dca |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T19:47:22Z |
| publishDate | 2013-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-977ef6ed0b2c46e6ad768ffd82594dca2023-08-02T03:26:21ZengMDPI AGBiology2079-77372013-07-0123976103310.3390/biology2030976The Role of Nuclear Bodies in Gene Expression and DiseaseMarie MorimotoCornelius F. BoerkoelThis review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, histone gene synthesis and nuclear RNA retention, has significant implications for gene regulation. These functional nuclear domains include the nucleolus, nuclear speckle, nuclear stress body, transcription factory, Cajal body, Gemini of Cajal body, histone locus body and paraspeckle. We herein review the roles of nuclear bodies in regulating gene expression and their relation to human health and disease.http://www.mdpi.com/2079-7737/2/3/976nuclear bodiestranscriptiongene expressiongenome organization |
| spellingShingle | Marie Morimoto Cornelius F. Boerkoel The Role of Nuclear Bodies in Gene Expression and Disease Biology nuclear bodies transcription gene expression genome organization |
| title | The Role of Nuclear Bodies in Gene Expression and Disease |
| title_full | The Role of Nuclear Bodies in Gene Expression and Disease |
| title_fullStr | The Role of Nuclear Bodies in Gene Expression and Disease |
| title_full_unstemmed | The Role of Nuclear Bodies in Gene Expression and Disease |
| title_short | The Role of Nuclear Bodies in Gene Expression and Disease |
| title_sort | role of nuclear bodies in gene expression and disease |
| topic | nuclear bodies transcription gene expression genome organization |
| url | http://www.mdpi.com/2079-7737/2/3/976 |
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