Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

Abstract Background Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers...

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Bibliographic Details
Main Authors: Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger, Rainer Claus
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Clinical Epigenetics
Subjects:
DNA-methylation
Epigenetics
HMA-treatment
Predictive biomarker
Predictive signature
DNA methylation patterns
Online Access:https://doi.org/10.1186/s13148-023-01580-z

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