<it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patients
<p>Abstract</p> <p>Background</p> <p>Single-nucleotide polymorphisms within <it>TP</it>53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and <it>MDM2 </it>promoter (SNP309; rs2279744), have been independently associated wi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-08-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | http://www.infectagentscancer.com/content/6/1/13 |
| _version_ | 1818583689268822016 |
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| author | Buonaguro Franco M Botti Gerardo Losito Simona Izzo Francesco Buonaguro Luigi Di Vuolo Valeria Tornesello Maria Lina |
| author_facet | Buonaguro Franco M Botti Gerardo Losito Simona Izzo Francesco Buonaguro Luigi Di Vuolo Valeria Tornesello Maria Lina |
| author_sort | Buonaguro Franco M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Single-nucleotide polymorphisms within <it>TP</it>53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and <it>MDM2 </it>promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types. Few studies have analysed the role of these polymorphisms in the development of hepatocellular carcinoma.</p> <p>Methods</p> <p>Genotype distribution of <it>TP</it>53 codon 72 and <it>MDM2 </it>SNP309 in 61 viral hepatitis-related hepatocellular carcinoma cases and 122 blood samples (healthy controls) from Italian subjects were determined by PCR and restriction fragment length polymorphism (RFLP).</p> <p>Results</p> <p>Frequencies of <it>TP</it>53 codon 72 alleles were not significantly different between cases and controls. A significant increase of <it>MDM2 </it>SNP309 G/G and T/G genotypes were observed among hepatocellular carcinoma cases (Odds Ratio, OR = 3.56, 95% Confidence Limits, 95% CI = 1.3-9.7; and OR = 2.82, 95% CI = 1.3-6.4, respectively).</p> <p>Conclusions</p> <p>These results highlight a significant role of <it>MDM2 </it>SNP309 G allele as a susceptibility gene for the development of viral hepatitis-related hepatocellular carcinoma among Italian subjects.</p> |
| first_indexed | 2024-12-16T08:09:16Z |
| format | Article |
| id | doaj.art-9780ba78200f4f80b1ffb6275721b69f |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-16T08:09:16Z |
| publishDate | 2011-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-9780ba78200f4f80b1ffb6275721b69f2022-12-21T22:38:23ZengBMCInfectious Agents and Cancer1750-93782011-08-01611310.1186/1750-9378-6-13<it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patientsBuonaguro Franco MBotti GerardoLosito SimonaIzzo FrancescoBuonaguro LuigiDi Vuolo ValeriaTornesello Maria Lina<p>Abstract</p> <p>Background</p> <p>Single-nucleotide polymorphisms within <it>TP</it>53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and <it>MDM2 </it>promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types. Few studies have analysed the role of these polymorphisms in the development of hepatocellular carcinoma.</p> <p>Methods</p> <p>Genotype distribution of <it>TP</it>53 codon 72 and <it>MDM2 </it>SNP309 in 61 viral hepatitis-related hepatocellular carcinoma cases and 122 blood samples (healthy controls) from Italian subjects were determined by PCR and restriction fragment length polymorphism (RFLP).</p> <p>Results</p> <p>Frequencies of <it>TP</it>53 codon 72 alleles were not significantly different between cases and controls. A significant increase of <it>MDM2 </it>SNP309 G/G and T/G genotypes were observed among hepatocellular carcinoma cases (Odds Ratio, OR = 3.56, 95% Confidence Limits, 95% CI = 1.3-9.7; and OR = 2.82, 95% CI = 1.3-6.4, respectively).</p> <p>Conclusions</p> <p>These results highlight a significant role of <it>MDM2 </it>SNP309 G allele as a susceptibility gene for the development of viral hepatitis-related hepatocellular carcinoma among Italian subjects.</p>http://www.infectagentscancer.com/content/6/1/13Genetic Polymorphisms<it>TP</it>53 codon 72<it>MDM2 </it>SNP309hepatocellular carcinoma |
| spellingShingle | Buonaguro Franco M Botti Gerardo Losito Simona Izzo Francesco Buonaguro Luigi Di Vuolo Valeria Tornesello Maria Lina <it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patients Infectious Agents and Cancer Genetic Polymorphisms <it>TP</it>53 codon 72 <it>MDM2 </it>SNP309 hepatocellular carcinoma |
| title | <it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patients |
| title_full | <it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patients |
| title_fullStr | <it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patients |
| title_full_unstemmed | <it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patients |
| title_short | <it>TP</it>53 and <it>MDM2 </it>gene polymorphisms and risk of hepatocellular carcinoma among Italian patients |
| title_sort | it tp it 53 and it mdm2 it gene polymorphisms and risk of hepatocellular carcinoma among italian patients |
| topic | Genetic Polymorphisms <it>TP</it>53 codon 72 <it>MDM2 </it>SNP309 hepatocellular carcinoma |
| url | http://www.infectagentscancer.com/content/6/1/13 |
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