Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

Host immune responses contribute to dengue’s pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. The pro-resolving protein Annexin A1 (AnxA1) is known to counterbalance overexuberant infl...

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Bibliographic Details
Main Authors: Vivian Vasconcelos Costa, Michelle A Sugimoto, Josy Hubner, Caio S Bonilha, Celso Martins Queiroz-Junior, Marcela Helena Gonçalves-Pereira, Jianmin Chen, Thomas Gobbetti, Gisele Olinto Libanio Rodrigues, Jordana L Bambirra, Ingredy B Passos, Carla Elizabeth Machado Lopes, Thaiane P Moreira, Kennedy Bonjour, Rossana CN Melo, Milton AP Oliveira, Marcus Vinicius M Andrade, Lirlândia Pires Sousa, Danielle Gloria Souza, Helton da Costa Santiago, Mauro Perretti, Mauro Martins Teixeira
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
dengue disease
Annexin A1 pro-resolving protein
FPR2/ALX receptor
inflammation resolution
Ac2-26 pro-resolving peptide
dengue virus
Online Access:https://elifesciences.org/articles/73853

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