Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study
Febrile neutropenia (FN) is a major concern in patients undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL); however, the overall risk of FN is difficult to assess. This study aimed to develop a model for predicting the occurrence of FN in patients with DLBCL. In this multicenter, retr...
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MDPI AG
2024-02-01
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| Series: | Hematology Reports |
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| Online Access: | https://www.mdpi.com/2038-8330/16/1/8 |
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| author | Masaya Morimoto Yuma Yokoya Kikuaki Yoshida Hideki Kosako Yoshikazu Hori Toshiki Mushino Shinobu Tamura Reiko Ito Ryosuke Koyamada Takuya Yamashita Shinichiro Mori Nobuyoshi Mori Sachiko Ohde |
| author_facet | Masaya Morimoto Yuma Yokoya Kikuaki Yoshida Hideki Kosako Yoshikazu Hori Toshiki Mushino Shinobu Tamura Reiko Ito Ryosuke Koyamada Takuya Yamashita Shinichiro Mori Nobuyoshi Mori Sachiko Ohde |
| author_sort | Masaya Morimoto |
| collection | DOAJ |
| description | Febrile neutropenia (FN) is a major concern in patients undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL); however, the overall risk of FN is difficult to assess. This study aimed to develop a model for predicting the occurrence of FN in patients with DLBCL. In this multicenter, retrospective, observational analysis, a multivariate logistic regression model was used to analyze the association between FN incidence and pretreatment clinical factors. We included adult inpatients and outpatients (aged ≥ 18 years) diagnosed with DLBCL who were treated with chemotherapy. The study examined 246 patients. Considering FN occurring during the first cycle of chemotherapy as the primary outcome, a predictive model with a total score of 5 points was constructed as follows: 1 point each for a positive hepatitis panel, extranodal involvement, and a high level of soluble interleukin-2 receptor and 2 points for lymphopenia. The area under the receiver operating characteristic curve of this model was 0.844 (95% confidence interval: 0.777–0.911). Our predictive model can assess the risk of FN before patients with DLBCL start chemotherapy, leading to better outcomes. |
| first_indexed | 2024-04-24T18:13:41Z |
| format | Article |
| id | doaj.art-9781e260be084a0e8295e6be2ab270d0 |
| institution | Directory Open Access Journal |
| issn | 2038-8330 |
| language | English |
| last_indexed | 2024-04-24T18:13:41Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-9781e260be084a0e8295e6be2ab270d02024-03-27T13:43:59ZengMDPI AGHematology Reports2038-83302024-02-01161768810.3390/hematolrep16010008Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational StudyMasaya Morimoto0Yuma Yokoya1Kikuaki Yoshida2Hideki Kosako3Yoshikazu Hori4Toshiki Mushino5Shinobu Tamura6Reiko Ito7Ryosuke Koyamada8Takuya Yamashita9Shinichiro Mori10Nobuyoshi Mori11Sachiko Ohde12Department of Hematology/Oncology, Kinan Hospital, Wakayama 646-8588, JapanDepartment of Hematology/Oncology, Kinan Hospital, Wakayama 646-8588, JapanDepartment of Hematology/Oncology, Kinan Hospital, Wakayama 646-8588, JapanDepartment of Hematology/Oncology, Kinan Hospital, Wakayama 646-8588, JapanDepartment of Hematology/Oncology, Kinan Hospital, Wakayama 646-8588, JapanDepartment of Hematology/Oncology, Kinan Hospital, Wakayama 646-8588, JapanDepartment of Hematology/Oncology, Kinan Hospital, Wakayama 646-8588, JapanDepartment of Hematology/Oncology, St. Luke’s International Hospital, Tokyo 104-0044, JapanDepartment of Hematology/Oncology, St. Luke’s International Hospital, Tokyo 104-0044, JapanDepartment of Hematology/Oncology, St. Luke’s International Hospital, Tokyo 104-0044, JapanDepartment of Hematology/Oncology, St. Luke’s International Hospital, Tokyo 104-0044, JapanDepartment of Infectious Diseases, St. Luke’s International Hospital, Tokyo 104-0044, JapanPublic Health, St. Luke’s International University, Tokyo 104-0044, JapanFebrile neutropenia (FN) is a major concern in patients undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL); however, the overall risk of FN is difficult to assess. This study aimed to develop a model for predicting the occurrence of FN in patients with DLBCL. In this multicenter, retrospective, observational analysis, a multivariate logistic regression model was used to analyze the association between FN incidence and pretreatment clinical factors. We included adult inpatients and outpatients (aged ≥ 18 years) diagnosed with DLBCL who were treated with chemotherapy. The study examined 246 patients. Considering FN occurring during the first cycle of chemotherapy as the primary outcome, a predictive model with a total score of 5 points was constructed as follows: 1 point each for a positive hepatitis panel, extranodal involvement, and a high level of soluble interleukin-2 receptor and 2 points for lymphopenia. The area under the receiver operating characteristic curve of this model was 0.844 (95% confidence interval: 0.777–0.911). Our predictive model can assess the risk of FN before patients with DLBCL start chemotherapy, leading to better outcomes.https://www.mdpi.com/2038-8330/16/1/8febrile neutropeniachemotherapydiffuse large B-cell lymphomaoutcomesmultivariate logistic regression model |
| spellingShingle | Masaya Morimoto Yuma Yokoya Kikuaki Yoshida Hideki Kosako Yoshikazu Hori Toshiki Mushino Shinobu Tamura Reiko Ito Ryosuke Koyamada Takuya Yamashita Shinichiro Mori Nobuyoshi Mori Sachiko Ohde Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study Hematology Reports febrile neutropenia chemotherapy diffuse large B-cell lymphoma outcomes multivariate logistic regression model |
| title | Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study |
| title_full | Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study |
| title_fullStr | Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study |
| title_full_unstemmed | Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study |
| title_short | Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study |
| title_sort | predictive model for occurrence of febrile neutropenia after chemotherapy in patients with diffuse large b cell lymphoma a multicenter retrospective observational study |
| topic | febrile neutropenia chemotherapy diffuse large B-cell lymphoma outcomes multivariate logistic regression model |
| url | https://www.mdpi.com/2038-8330/16/1/8 |
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