Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip
Background: Deep Vein Thrombosis (DVT) is a common disease, frequently afflicting the lower limb veins of bedridden patients. Intermittent Pneumatic Compression (IPC) is often employed as an effective solution for this problem. In our study, a random selection of 264 patients underwent IPC treatment...
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| Format: | Article |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1281503/full |
| _version_ | 1827763366024708096 |
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| author | Hongtao Dai Senlin Chai Yao Yao Wenlai Tang Wenlai Tang Jianping Shi Qing Jiang Liya Zhu |
| author_facet | Hongtao Dai Senlin Chai Yao Yao Wenlai Tang Wenlai Tang Jianping Shi Qing Jiang Liya Zhu |
| author_sort | Hongtao Dai |
| collection | DOAJ |
| description | Background: Deep Vein Thrombosis (DVT) is a common disease, frequently afflicting the lower limb veins of bedridden patients. Intermittent Pneumatic Compression (IPC) is often employed as an effective solution for this problem. In our study, a random selection of 264 patients underwent IPC treatment for either one or 8 hours daily. The rate of severe venous thrombosis was substantially reduced in the IPC-treated group compared to the control group. However, real-time monitoring of blood flow during IPC operation periods remains a challenge, leading to rare awareness of IPC working mechanism on thrombosis prevention.Methods: Here, microfluidic chip methodology is used to create an in vitro vein-mimicking platform integrating venous valves in a deformable channel. Whole blood of patients after knee surgery was perfused into the venous channel at a controlled flow rate obtained from patients with IPC treatment clinically.Results: According to the numerical simulations results, both of an increase in compressive pressure and a decrease in time interval of IPC device can accelarete blood flow rate and the shear stress within the vein. The vein chip experiments also reveal that the fibrin accumulation can be greatly lowered in IPC treated group, indicating less thrombosis formation in future. A time interval of 24 seconds and a maximum contraction pressure of 40 mmHg were proved to be the most effective parameters for the IPC device adopted in our clinical trail.Conclusion: This vein chip presents a novel method for observing the functional mechanisms of IPC device for DVT prevention. It provides crucial data for further standardization and optimization of IPC devices in clinical usage. |
| first_indexed | 2024-03-11T10:51:10Z |
| format | Article |
| id | doaj.art-978302172cd74cd48f0d867bcc4b7d82 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-11T10:51:10Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-978302172cd74cd48f0d867bcc4b7d822023-11-13T17:59:24ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-11-011110.3389/fbioe.2023.12815031281503Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chipHongtao Dai0Senlin Chai1Yao Yao2Wenlai Tang3Wenlai Tang4Jianping Shi5Qing Jiang6Liya Zhu7Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing University, Nanjing, ChinaJiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing, ChinaGuangdong Key Laboratory of Minimally Invasive Surgical Instruments and Manufacturing Technology, School of Electromechanically Engineering, Guangdong University of Technology, Guangzhou, ChinaJiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing University, Nanjing, ChinaJiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing, ChinaBackground: Deep Vein Thrombosis (DVT) is a common disease, frequently afflicting the lower limb veins of bedridden patients. Intermittent Pneumatic Compression (IPC) is often employed as an effective solution for this problem. In our study, a random selection of 264 patients underwent IPC treatment for either one or 8 hours daily. The rate of severe venous thrombosis was substantially reduced in the IPC-treated group compared to the control group. However, real-time monitoring of blood flow during IPC operation periods remains a challenge, leading to rare awareness of IPC working mechanism on thrombosis prevention.Methods: Here, microfluidic chip methodology is used to create an in vitro vein-mimicking platform integrating venous valves in a deformable channel. Whole blood of patients after knee surgery was perfused into the venous channel at a controlled flow rate obtained from patients with IPC treatment clinically.Results: According to the numerical simulations results, both of an increase in compressive pressure and a decrease in time interval of IPC device can accelarete blood flow rate and the shear stress within the vein. The vein chip experiments also reveal that the fibrin accumulation can be greatly lowered in IPC treated group, indicating less thrombosis formation in future. A time interval of 24 seconds and a maximum contraction pressure of 40 mmHg were proved to be the most effective parameters for the IPC device adopted in our clinical trail.Conclusion: This vein chip presents a novel method for observing the functional mechanisms of IPC device for DVT prevention. It provides crucial data for further standardization and optimization of IPC devices in clinical usage.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1281503/fullintermittent pneumatic compressiondeep vein thrombosismicrofludic vein chipblood flownumerical method |
| spellingShingle | Hongtao Dai Senlin Chai Yao Yao Wenlai Tang Wenlai Tang Jianping Shi Qing Jiang Liya Zhu Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip Frontiers in Bioengineering and Biotechnology intermittent pneumatic compression deep vein thrombosis microfludic vein chip blood flow numerical method |
| title | Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip |
| title_full | Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip |
| title_fullStr | Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip |
| title_full_unstemmed | Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip |
| title_short | Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip |
| title_sort | effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip |
| topic | intermittent pneumatic compression deep vein thrombosis microfludic vein chip blood flow numerical method |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1281503/full |
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