| Summary: | Invasion and metastasis correspond to the foremost cause of cancer-related death, and the molecular networks behind these two processes are extremely complex and dependent on the intra- and extracellular conditions along with the prime of the premetastatic niche. Currently, several studies suggest an association between the levels of <i>HOX</i> genes expression and cancer cell invasion and metastasis, which favour the formation of novel tumour masses. The deregulation of <i>HOX</i> genes by HMGA2/TET1 signalling and the regulatory effect of noncoding RNAs generated by the <i>HOX</i> loci can also promote invasion and metastasis, interfering with the expression of <i>HOX</i> genes or other genes relevant to these processes. In this review, we present five molecular mechanisms of <i>HOX</i> deregulation by which the <i>HOX</i> clusters products may affect invasion and metastatic processes in solid tumours.
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