Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport
Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observ...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2016-03-01
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| Series: | Physical Review X |
| Online Access: | http://doi.org/10.1103/PhysRevX.6.011037 |
| _version_ | 1818401240086740992 |
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| author | Monika Scholz Stanislav Burov Kimberly L. Weirich Björn J. Scholz S. M. Ali Tabei Margaret L. Gardel Aaron R. Dinner |
| author_facet | Monika Scholz Stanislav Burov Kimberly L. Weirich Björn J. Scholz S. M. Ali Tabei Margaret L. Gardel Aaron R. Dinner |
| author_sort | Monika Scholz |
| collection | DOAJ |
| description | Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortexlike state can account for the power-law dwell times. We identify trends in the dynamics with the motor valency for further experimental validation. We demonstrate that these trends exist in individual trajectories of myosin II on an actin network. We discuss how cells could regulate intracellular transport and, in turn, biological function by controlling their cytoskeletal network structures locally. |
| first_indexed | 2024-12-14T07:49:19Z |
| format | Article |
| id | doaj.art-97834781e3d24a269ce860cc65bb3d4d |
| institution | Directory Open Access Journal |
| issn | 2160-3308 |
| language | English |
| last_indexed | 2024-12-14T07:49:19Z |
| publishDate | 2016-03-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review X |
| spelling | doaj.art-97834781e3d24a269ce860cc65bb3d4d2022-12-21T23:10:47ZengAmerican Physical SocietyPhysical Review X2160-33082016-03-016101103710.1103/PhysRevX.6.011037Cycling State that Can Lead to Glassy Dynamics in Intracellular TransportMonika ScholzStanislav BurovKimberly L. WeirichBjörn J. ScholzS. M. Ali TabeiMargaret L. GardelAaron R. DinnerPower-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortexlike state can account for the power-law dwell times. We identify trends in the dynamics with the motor valency for further experimental validation. We demonstrate that these trends exist in individual trajectories of myosin II on an actin network. We discuss how cells could regulate intracellular transport and, in turn, biological function by controlling their cytoskeletal network structures locally.http://doi.org/10.1103/PhysRevX.6.011037 |
| spellingShingle | Monika Scholz Stanislav Burov Kimberly L. Weirich Björn J. Scholz S. M. Ali Tabei Margaret L. Gardel Aaron R. Dinner Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport Physical Review X |
| title | Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport |
| title_full | Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport |
| title_fullStr | Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport |
| title_full_unstemmed | Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport |
| title_short | Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport |
| title_sort | cycling state that can lead to glassy dynamics in intracellular transport |
| url | http://doi.org/10.1103/PhysRevX.6.011037 |
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