Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> Extract
This study aimed to develop a <i>Kaempferia parviflora</i> (KP) extract based on electrospun shellac fibers capable of transporting methoxyflavones. This study used a Box–Behnken design to determine the optimal production parameters that influence the fiber diameter and bead-to-fiber rat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/123 |
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| author | Wantanwa Krongrawa Sontaya Limmatvapirat Mont Kumpugdee Vollrath Prasat Kittakoop Supachai Saibua Chutima Limmatvapirat |
| author_facet | Wantanwa Krongrawa Sontaya Limmatvapirat Mont Kumpugdee Vollrath Prasat Kittakoop Supachai Saibua Chutima Limmatvapirat |
| author_sort | Wantanwa Krongrawa |
| collection | DOAJ |
| description | This study aimed to develop a <i>Kaempferia parviflora</i> (KP) extract based on electrospun shellac fibers capable of transporting methoxyflavones. This study used a Box–Behnken design to determine the optimal production parameters that influence the fiber diameter and bead-to-fiber ratio responses. The optimization step produced fibers with a small diameter (574 nm) and a lower bead-to-fiber ratio (0.48 beads per fiber) by combining 37.25% <i>w</i>/<i>w</i> shellac and 1.50% <i>w</i>/<i>w</i> KP extract with a solution feed rate of 0.8 mL/h and an electrical voltage of 18 kV. The KP extract was found to be dispersed throughout the electrospun shellac fibers during the characterization study. The results were highly correlated with the theoretical values, indicating that the regression models used to predict the response variables were adequate. A study of in vitro dissolution confirmed that KP extract-loaded electrospun shellac fibers could produce a sustained-release profile within 10 h. Additionally, KP-infused shellac fibers demonstrated antibacterial activity against <i>Staphylococcus aureus</i>. This KP loading method combined with shellac properties provided a new delivery system and could be used to explore novel biomedical materials. |
| first_indexed | 2024-03-09T11:27:43Z |
| format | Article |
| id | doaj.art-9785065723264774aadd61183bc26614 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:27:43Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9785065723264774aadd61183bc266142023-11-30T23:58:00ZengMDPI AGPharmaceutics1999-49232022-12-0115112310.3390/pharmaceutics15010123Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> ExtractWantanwa Krongrawa0Sontaya Limmatvapirat1Mont Kumpugdee Vollrath2Prasat Kittakoop3Supachai Saibua4Chutima Limmatvapirat5Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandLaboratory Pharmaceutical Technology, Faculty II-Mathematics-Physics-Chemistry, Berliner Hochschule für Technik, Luxemburger Str.10, 13353 Berlin, GermanyChulabhorn Graduate Institute, Program in Chemical Sciences, Chulabhorn Royal Academy, Bangkok 10210, ThailandBangkok Lab & Cosmetic Co., Ltd., 48/1, Moo 5, Nongsaesao Road, Tambon Namphu, Amphoe Muang Ratchaburi, Ratchaburi 70000, ThailandDepartment of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandThis study aimed to develop a <i>Kaempferia parviflora</i> (KP) extract based on electrospun shellac fibers capable of transporting methoxyflavones. This study used a Box–Behnken design to determine the optimal production parameters that influence the fiber diameter and bead-to-fiber ratio responses. The optimization step produced fibers with a small diameter (574 nm) and a lower bead-to-fiber ratio (0.48 beads per fiber) by combining 37.25% <i>w</i>/<i>w</i> shellac and 1.50% <i>w</i>/<i>w</i> KP extract with a solution feed rate of 0.8 mL/h and an electrical voltage of 18 kV. The KP extract was found to be dispersed throughout the electrospun shellac fibers during the characterization study. The results were highly correlated with the theoretical values, indicating that the regression models used to predict the response variables were adequate. A study of in vitro dissolution confirmed that KP extract-loaded electrospun shellac fibers could produce a sustained-release profile within 10 h. Additionally, KP-infused shellac fibers demonstrated antibacterial activity against <i>Staphylococcus aureus</i>. This KP loading method combined with shellac properties provided a new delivery system and could be used to explore novel biomedical materials.https://www.mdpi.com/1999-4923/15/1/123electrospun fibershellac<i>Kaempferia parviflora</i>Box–Behnken designdissolutionmethoxyflavones |
| spellingShingle | Wantanwa Krongrawa Sontaya Limmatvapirat Mont Kumpugdee Vollrath Prasat Kittakoop Supachai Saibua Chutima Limmatvapirat Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> Extract Pharmaceutics electrospun fiber shellac <i>Kaempferia parviflora</i> Box–Behnken design dissolution methoxyflavones |
| title | Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> Extract |
| title_full | Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> Extract |
| title_fullStr | Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> Extract |
| title_full_unstemmed | Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> Extract |
| title_short | Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with <i>Kaempferia parviflora</i> Extract |
| title_sort | fabrication optimization and characterization of antibacterial electrospun shellac fibers loaded with i kaempferia parviflora i extract |
| topic | electrospun fiber shellac <i>Kaempferia parviflora</i> Box–Behnken design dissolution methoxyflavones |
| url | https://www.mdpi.com/1999-4923/15/1/123 |
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