p53 and FBXW7: Sometimes Two Guardians Are Worse than One
Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/4/985 |
| _version_ | 1797570492247310336 |
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| author | María Galindo-Moreno Servando Giráldez M. Cristina Limón-Mortés Alejandro Belmonte-Fernández Carmen Sáez Miguel Á. Japón Maria Tortolero Francisco Romero |
| author_facet | María Galindo-Moreno Servando Giráldez M. Cristina Limón-Mortés Alejandro Belmonte-Fernández Carmen Sáez Miguel Á. Japón Maria Tortolero Francisco Romero |
| author_sort | María Galindo-Moreno |
| collection | DOAJ |
| description | Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in tumor cell development. We also speculate about the function of FBXW7 as a key player in the cell fate after DNA damage and how this could be exploited in the treatment of cancer disease. |
| first_indexed | 2024-03-10T20:25:20Z |
| format | Article |
| id | doaj.art-97886de1e2f046b1acaf0d1938cca885 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:25:20Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-97886de1e2f046b1acaf0d1938cca8852023-11-19T21:49:40ZengMDPI AGCancers2072-66942020-04-0112498510.3390/cancers12040985p53 and FBXW7: Sometimes Two Guardians Are Worse than OneMaría Galindo-Moreno0Servando Giráldez1M. Cristina Limón-Mortés2Alejandro Belmonte-Fernández3Carmen Sáez4Miguel Á. Japón5Maria Tortolero6Francisco Romero7Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, E-41012 Sevilla, SpainDepartamento de Microbiología, Facultad de Biología, Universidad de Sevilla, E-41012 Sevilla, SpainDepartamento de Microbiología, Facultad de Biología, Universidad de Sevilla, E-41012 Sevilla, SpainDepartamento de Microbiología, Facultad de Biología, Universidad de Sevilla, E-41012 Sevilla, SpainInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, E-41013 Sevilla, SpainInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, E-41013 Sevilla, SpainDepartamento de Microbiología, Facultad de Biología, Universidad de Sevilla, E-41012 Sevilla, SpainDepartamento de Microbiología, Facultad de Biología, Universidad de Sevilla, E-41012 Sevilla, SpainToo much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in tumor cell development. We also speculate about the function of FBXW7 as a key player in the cell fate after DNA damage and how this could be exploited in the treatment of cancer disease.https://www.mdpi.com/2072-6694/12/4/985FBXW7p53tumor suppressorcancerproliferationubiquitylation |
| spellingShingle | María Galindo-Moreno Servando Giráldez M. Cristina Limón-Mortés Alejandro Belmonte-Fernández Carmen Sáez Miguel Á. Japón Maria Tortolero Francisco Romero p53 and FBXW7: Sometimes Two Guardians Are Worse than One Cancers FBXW7 p53 tumor suppressor cancer proliferation ubiquitylation |
| title | p53 and FBXW7: Sometimes Two Guardians Are Worse than One |
| title_full | p53 and FBXW7: Sometimes Two Guardians Are Worse than One |
| title_fullStr | p53 and FBXW7: Sometimes Two Guardians Are Worse than One |
| title_full_unstemmed | p53 and FBXW7: Sometimes Two Guardians Are Worse than One |
| title_short | p53 and FBXW7: Sometimes Two Guardians Are Worse than One |
| title_sort | p53 and fbxw7 sometimes two guardians are worse than one |
| topic | FBXW7 p53 tumor suppressor cancer proliferation ubiquitylation |
| url | https://www.mdpi.com/2072-6694/12/4/985 |
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