p53 and FBXW7: Sometimes Two Guardians Are Worse than One

p53 and FBXW7: Sometimes Two Guardians Are Worse than One

Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in...

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Bibliographic Details
Main Authors: María Galindo-Moreno, Servando Giráldez, M. Cristina Limón-Mortés, Alejandro Belmonte-Fernández, Carmen Sáez, Miguel Á. Japón, Maria Tortolero, Francisco Romero
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
FBXW7
p53
tumor suppressor
cancer
proliferation
ubiquitylation
Online Access:https://www.mdpi.com/2072-6694/12/4/985

Internet

https://www.mdpi.com/2072-6694/12/4/985

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