Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer
Abstract Objective This study aimed to identify the influential factors for the sensitivity of epidermal growth factor receptor (EGFR) plasma test in non-small cell lung cancer (NSCLC). The mutations were detected in tumor tissue and matched plasma samples from 125 newly diagnosed adenocarcinoma, cl...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-020-05209-9 |
| _version_ | 1819119724809682944 |
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| author | Vinh Thanh Tran Thang Thanh Phan Son Truong Nguyen Bich-Thu Tran Toan Trong Ho Suong Phuoc Pho Tran Bao Nguyen Tuyen Thi Bich Pham Anh Tuan Le Vu Thuong Le Hang Thuy Nguyen |
| author_facet | Vinh Thanh Tran Thang Thanh Phan Son Truong Nguyen Bich-Thu Tran Toan Trong Ho Suong Phuoc Pho Tran Bao Nguyen Tuyen Thi Bich Pham Anh Tuan Le Vu Thuong Le Hang Thuy Nguyen |
| author_sort | Vinh Thanh Tran |
| collection | DOAJ |
| description | Abstract Objective This study aimed to identify the influential factors for the sensitivity of epidermal growth factor receptor (EGFR) plasma test in non-small cell lung cancer (NSCLC). The mutations were detected in tumor tissue and matched plasma samples from 125 newly diagnosed adenocarcinoma, clinical-stage IIIB-IV patients, and compared the diagnostic values of EGFR plasma test between groups of clinical characteristics. The influential factors for the sensitivity were identified and assessed by logistic regression. Results EGFR mutations were detected in 65 (52.0%) tumor tissue and 50 (40.0%) matched plasma samples (P = 0.028). Compared to the tissue method, the concordance rate, sensitivity, and specificity of the EGFR plasma test were 86.4%, 75.4%, and 98.3%, respectively. Notably, we found that sensitivity of the test is higher in non-smokers (84.1%) compared to smokers (57.1%, P = 0.018), and in treatment naïve subjects (85.7%) compared to whom undergone chemo-radiotherapy with/without surgery before testing (56.5%, P = 0.009). Furthermore, the highest sensitivity was attained in patients without these two factors (90.3%), whilst the lowest value was noted in those with both factors (40.0%, P = 0.004). The multivariable analysis confirmed that smoking habit and treatment history have independently negative impacts on sensitivity (OR = 0.24, P = 0.019, and OR = 0.36, P = 0.047, respectively). |
| first_indexed | 2024-12-22T06:09:19Z |
| format | Article |
| id | doaj.art-978a314c60044a8babf354e62b2367fb |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-22T06:09:19Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-978a314c60044a8babf354e62b2367fb2022-12-21T18:36:17ZengBMCBMC Research Notes1756-05002020-08-011311710.1186/s13104-020-05209-9Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancerVinh Thanh Tran0Thang Thanh Phan1Son Truong Nguyen2Bich-Thu Tran3Toan Trong Ho4Suong Phuoc Pho5Tran Bao Nguyen6Tuyen Thi Bich Pham7Anh Tuan Le8Vu Thuong Le9Hang Thuy Nguyen10The Laboratory D Unit, Clinical Cancer Center, Cho Ray HospitalThe Laboratory D Unit, Clinical Cancer Center, Cho Ray HospitalThe Laboratory D Unit, Clinical Cancer Center, Cho Ray HospitalFaculty of Biology-Biotechnology, University of Science, VNU-HCMThe Laboratory D Unit, Clinical Cancer Center, Cho Ray HospitalThe Laboratory D Unit, Clinical Cancer Center, Cho Ray HospitalThe Laboratory D Unit, Clinical Cancer Center, Cho Ray HospitalThe Laboratory D Unit, Clinical Cancer Center, Cho Ray HospitalDepartment of Chemo-Radiotherapy, Clinical Cancer Center, Cho Ray HospitalDepartment of Thoracic Disease, Cho Ray HospitalDepartment of Clinical Pathology, Cho Ray HospitalAbstract Objective This study aimed to identify the influential factors for the sensitivity of epidermal growth factor receptor (EGFR) plasma test in non-small cell lung cancer (NSCLC). The mutations were detected in tumor tissue and matched plasma samples from 125 newly diagnosed adenocarcinoma, clinical-stage IIIB-IV patients, and compared the diagnostic values of EGFR plasma test between groups of clinical characteristics. The influential factors for the sensitivity were identified and assessed by logistic regression. Results EGFR mutations were detected in 65 (52.0%) tumor tissue and 50 (40.0%) matched plasma samples (P = 0.028). Compared to the tissue method, the concordance rate, sensitivity, and specificity of the EGFR plasma test were 86.4%, 75.4%, and 98.3%, respectively. Notably, we found that sensitivity of the test is higher in non-smokers (84.1%) compared to smokers (57.1%, P = 0.018), and in treatment naïve subjects (85.7%) compared to whom undergone chemo-radiotherapy with/without surgery before testing (56.5%, P = 0.009). Furthermore, the highest sensitivity was attained in patients without these two factors (90.3%), whilst the lowest value was noted in those with both factors (40.0%, P = 0.004). The multivariable analysis confirmed that smoking habit and treatment history have independently negative impacts on sensitivity (OR = 0.24, P = 0.019, and OR = 0.36, P = 0.047, respectively).http://link.springer.com/article/10.1186/s13104-020-05209-9EGFR mutationscfDNANSCLCSensitivity |
| spellingShingle | Vinh Thanh Tran Thang Thanh Phan Son Truong Nguyen Bich-Thu Tran Toan Trong Ho Suong Phuoc Pho Tran Bao Nguyen Tuyen Thi Bich Pham Anh Tuan Le Vu Thuong Le Hang Thuy Nguyen Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer BMC Research Notes EGFR mutations cfDNA NSCLC Sensitivity |
| title | Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer |
| title_full | Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer |
| title_fullStr | Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer |
| title_full_unstemmed | Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer |
| title_short | Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer |
| title_sort | smoking habit and chemo radiotherapy and or surgery affect the sensitivity of egfr plasma test in non small cell lung cancer |
| topic | EGFR mutations cfDNA NSCLC Sensitivity |
| url | http://link.springer.com/article/10.1186/s13104-020-05209-9 |
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