A Limited and Diverse Set of Suppressor Mutations Restore Function to INX-8 Mutant Hemichannels in the <i>Caenorhabditis elegans</i> Somatic Gonad

A Limited and Diverse Set of Suppressor Mutations Restore Function to INX-8 Mutant Hemichannels in the <i>Caenorhabditis elegans</i> Somatic Gonad

In <i>Caenorhabditis elegans</i>, gap junctions couple cells of the somatic gonad with the germline to support germ cell proliferation and gametogenesis. A strong loss-of-function mutation (T239I) affects the second extracellular loop (EL2) of the somatic INX-8 hemichannel subunit. These...

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Bibliographic Details
Main Authors: Todd Starich, David Greenstein
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
gap junctions
innexins
soma–germline interactions
Online Access:https://www.mdpi.com/2218-273X/10/12/1655

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