Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

Abstract During tumor progression, a subset of cancer cells escape from immune surveillance and eventually develop into measurable tumor mass. Cancer immunotherapy eradicates tumor cells by enhancing multiple steps in cancer-immunity cycle including antigen presentation, T cell priming, activation,...

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Bibliographic Details
Main Authors: Anping Li, Ming Yi, Shuang Qin, Yongping Song, Qian Chu, Kongming Wu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Hematology & Oncology
Subjects:
cGAS-STING
Innate immunity
Type I interferon
Cancer immunotherapy
CAR-T
Immune checkpoint inhibitor
Online Access:http://link.springer.com/article/10.1186/s13045-019-0721-x

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