Regulation of adult stem cell function by ketone bodies
Adult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore potentially be manipulated through dietary re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1246998/full |
| _version_ | 1827855413055324160 |
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| author | Ole Emil Andersen Ole Emil Andersen Jens Vase Poulsen Jean Farup Jean Farup Antoine de Morree |
| author_facet | Ole Emil Andersen Ole Emil Andersen Jens Vase Poulsen Jean Farup Jean Farup Antoine de Morree |
| author_sort | Ole Emil Andersen |
| collection | DOAJ |
| description | Adult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore potentially be manipulated through dietary regimens or exogenous ketone body supplementation, a possibility with significant implications for regenerative medicine. In this review we discuss recent findings of the mechanisms by which ketone bodies could influence adult stem cells, including ketogenesis in adult stem cells, uptake and transport of circulating ketone bodies, receptor-mediated signaling, and changes to cellular metabolism. We also discuss the potential effects of ketone bodies on intracellular processes such as protein acetylation and post-transcriptional control of gene expression. The exploration of mechanisms underlying the effects of ketone bodies on stem cell function reveals potential therapeutic targets for tissue regeneration and age-related diseases and suggests future research directions in the field of ketone bodies and stem cells. |
| first_indexed | 2024-03-12T11:49:51Z |
| format | Article |
| id | doaj.art-978ea487084e4b1d8cb1c4d9b4c89793 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-12T11:49:51Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-978ea487084e4b1d8cb1c4d9b4c897932023-08-31T10:08:58ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-08-011110.3389/fcell.2023.12469981246998Regulation of adult stem cell function by ketone bodiesOle Emil Andersen0Ole Emil Andersen1Jens Vase Poulsen2Jean Farup3Jean Farup4Antoine de Morree5Department of Public Health, Aarhus University, Aarhus, DenmarkSteno Diabetes Center Aarhus, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine, Aarhus University, Aarhus, DenmarkSteno Diabetes Center Aarhus, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine, Aarhus University, Aarhus, DenmarkAdult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore potentially be manipulated through dietary regimens or exogenous ketone body supplementation, a possibility with significant implications for regenerative medicine. In this review we discuss recent findings of the mechanisms by which ketone bodies could influence adult stem cells, including ketogenesis in adult stem cells, uptake and transport of circulating ketone bodies, receptor-mediated signaling, and changes to cellular metabolism. We also discuss the potential effects of ketone bodies on intracellular processes such as protein acetylation and post-transcriptional control of gene expression. The exploration of mechanisms underlying the effects of ketone bodies on stem cell function reveals potential therapeutic targets for tissue regeneration and age-related diseases and suggests future research directions in the field of ketone bodies and stem cells.https://www.frontiersin.org/articles/10.3389/fcell.2023.1246998/fulladult stem cellsketone bodiesstem cell functionregenerative medicinetissue homeostasiscellular metabolism |
| spellingShingle | Ole Emil Andersen Ole Emil Andersen Jens Vase Poulsen Jean Farup Jean Farup Antoine de Morree Regulation of adult stem cell function by ketone bodies Frontiers in Cell and Developmental Biology adult stem cells ketone bodies stem cell function regenerative medicine tissue homeostasis cellular metabolism |
| title | Regulation of adult stem cell function by ketone bodies |
| title_full | Regulation of adult stem cell function by ketone bodies |
| title_fullStr | Regulation of adult stem cell function by ketone bodies |
| title_full_unstemmed | Regulation of adult stem cell function by ketone bodies |
| title_short | Regulation of adult stem cell function by ketone bodies |
| title_sort | regulation of adult stem cell function by ketone bodies |
| topic | adult stem cells ketone bodies stem cell function regenerative medicine tissue homeostasis cellular metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1246998/full |
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