A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid
As an important biomarker in urine, the level of uric acid is of importance for human health. In this work, a Cu(II) functionalized metal–organic framework (Cu<sup>2+</sup>@Tb-MOFs) is designed and developed as a novel fluorescence probe for wide-range uric acid detection in human urine....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/15/4803 |
| _version_ | 1827602099295223808 |
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| author | Jie Yang Jie Che Xin Jiang Yangchun Fan Daojiang Gao Jian Bi Zhanglei Ning |
| author_facet | Jie Yang Jie Che Xin Jiang Yangchun Fan Daojiang Gao Jian Bi Zhanglei Ning |
| author_sort | Jie Yang |
| collection | DOAJ |
| description | As an important biomarker in urine, the level of uric acid is of importance for human health. In this work, a Cu(II) functionalized metal–organic framework (Cu<sup>2+</sup>@Tb-MOFs) is designed and developed as a novel fluorescence probe for wide-range uric acid detection in human urine. The study shows that this fluorescence platform demonstrated excellent pH-independent stability, high water tolerance, and good thermal stability. Based on the strong interaction between metal ions and uric acid, the designed Cu<sup>2+</sup>@Tb-MOFs can be employed as efficient turn-on fluorescent probes for the detection of uric acid with wide detection range (0~10<sup>4</sup> µM) and high sensitivity (LOD = 0.65 µM). This probe also demonstrates an anti-interference property, as other species coexisted, and the possibility for recycling. The sensing mechanisms are further discussed at length. More importantly, we experimentally constructed a molecular logic gate operation based on this fluorescence probe for intelligent detection of uric acid. These results suggest the Cu(II) functionalized metal–organic framework can act as a prominent candidate for personalized monitoring of the concentration of uric acid in the human urine system. |
| first_indexed | 2024-03-09T05:11:13Z |
| format | Article |
| id | doaj.art-9790d85ab5024a2980e08ae77aea77d4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:11:13Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9790d85ab5024a2980e08ae77aea77d42023-12-03T12:49:47ZengMDPI AGMolecules1420-30492022-07-012715480310.3390/molecules27154803A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric AcidJie Yang0Jie Che1Xin Jiang2Yangchun Fan3Daojiang Gao4Jian Bi5Zhanglei Ning6College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, ChinaCollege of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, ChinaCollege of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, ChinaCollege of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, ChinaCollege of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, ChinaCollege of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, ChinaCollege of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, ChinaAs an important biomarker in urine, the level of uric acid is of importance for human health. In this work, a Cu(II) functionalized metal–organic framework (Cu<sup>2+</sup>@Tb-MOFs) is designed and developed as a novel fluorescence probe for wide-range uric acid detection in human urine. The study shows that this fluorescence platform demonstrated excellent pH-independent stability, high water tolerance, and good thermal stability. Based on the strong interaction between metal ions and uric acid, the designed Cu<sup>2+</sup>@Tb-MOFs can be employed as efficient turn-on fluorescent probes for the detection of uric acid with wide detection range (0~10<sup>4</sup> µM) and high sensitivity (LOD = 0.65 µM). This probe also demonstrates an anti-interference property, as other species coexisted, and the possibility for recycling. The sensing mechanisms are further discussed at length. More importantly, we experimentally constructed a molecular logic gate operation based on this fluorescence probe for intelligent detection of uric acid. These results suggest the Cu(II) functionalized metal–organic framework can act as a prominent candidate for personalized monitoring of the concentration of uric acid in the human urine system.https://www.mdpi.com/1420-3049/27/15/4803metal–organic frameworksprobedetectionuric acidlogic gate |
| spellingShingle | Jie Yang Jie Che Xin Jiang Yangchun Fan Daojiang Gao Jian Bi Zhanglei Ning A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid Molecules metal–organic frameworks probe detection uric acid logic gate |
| title | A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid |
| title_full | A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid |
| title_fullStr | A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid |
| title_full_unstemmed | A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid |
| title_short | A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid |
| title_sort | novel turn on fluorescence probe based on cu ii functionalized metal organic frameworks for visual detection of uric acid |
| topic | metal–organic frameworks probe detection uric acid logic gate |
| url | https://www.mdpi.com/1420-3049/27/15/4803 |
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