A neural circuit for gastric motility disorders driven by gastric dilation in mice
IntroductionSymptoms of gastric motility disorders are common clinical manifestations of functional gastrointestinal disorders (FGIDs), and are triggered and exacerbated by stress, but the neural pathways underpinning them remain unclear.MethodsWe set-up a mouse model by gastric dilation (GD) in whi...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1069198/full |
| _version_ | 1797900437087584256 |
|---|---|
| author | Xi-yang Wang Xiao-qi Chen Guo-quan Wang Rong-lin Cai Hao Wang Hai-tao Wang Xiao-qi Peng Meng-ting Zhang Shun Huang Guo-ming Shen Guo-ming Shen |
| author_facet | Xi-yang Wang Xiao-qi Chen Guo-quan Wang Rong-lin Cai Hao Wang Hai-tao Wang Xiao-qi Peng Meng-ting Zhang Shun Huang Guo-ming Shen Guo-ming Shen |
| author_sort | Xi-yang Wang |
| collection | DOAJ |
| description | IntroductionSymptoms of gastric motility disorders are common clinical manifestations of functional gastrointestinal disorders (FGIDs), and are triggered and exacerbated by stress, but the neural pathways underpinning them remain unclear.MethodsWe set-up a mouse model by gastric dilation (GD) in which the gastric dynamics were assessed by installing strain gauges on the surface of the stomach. The neural pathway associated with gastric motility disorders was investigated by behavioral tests, electrophysiology, neural circuit tracing, and optogenetics and chemogenetics involving projections of the corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN) to acetylcholine (ChAT) neurons in the dorsal motor nucleus of the vagus (DMV).ResultsWe found that GD induced gastric motility disorders were accompanied by activation of PVNCRH neurons, which could be alleviated by strategies that inhibits the activity of PVNCRH neurons. In addition, we identified a neural pathway in which PVNCRH neurons project into DMVChAT neurons, modulated activity of the PVNCRH→DMVChAT pathway to alleviate gastric motility disorders induced by GD.DiscussionThese findings indicate that the PVNCRH→DMVChAT pathway may mediate at least some aspects of GD related gastric motility, and provide new insights into the mechanisms by which somatic stimulation modulates the physiological functions of internal organs and systems. |
| first_indexed | 2024-04-10T08:46:01Z |
| format | Article |
| id | doaj.art-9791434bfcd2495c9871419a55705f9d |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T08:46:01Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-9791434bfcd2495c9871419a55705f9d2023-02-22T08:37:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-02-011710.3389/fnins.2023.10691981069198A neural circuit for gastric motility disorders driven by gastric dilation in miceXi-yang Wang0Xiao-qi Chen1Guo-quan Wang2Rong-lin Cai3Hao Wang4Hai-tao Wang5Xiao-qi Peng6Meng-ting Zhang7Shun Huang8Guo-ming Shen9Guo-ming Shen10School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaResearch Institute of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaSchool of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, ChinaSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaInstitute of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaIntroductionSymptoms of gastric motility disorders are common clinical manifestations of functional gastrointestinal disorders (FGIDs), and are triggered and exacerbated by stress, but the neural pathways underpinning them remain unclear.MethodsWe set-up a mouse model by gastric dilation (GD) in which the gastric dynamics were assessed by installing strain gauges on the surface of the stomach. The neural pathway associated with gastric motility disorders was investigated by behavioral tests, electrophysiology, neural circuit tracing, and optogenetics and chemogenetics involving projections of the corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN) to acetylcholine (ChAT) neurons in the dorsal motor nucleus of the vagus (DMV).ResultsWe found that GD induced gastric motility disorders were accompanied by activation of PVNCRH neurons, which could be alleviated by strategies that inhibits the activity of PVNCRH neurons. In addition, we identified a neural pathway in which PVNCRH neurons project into DMVChAT neurons, modulated activity of the PVNCRH→DMVChAT pathway to alleviate gastric motility disorders induced by GD.DiscussionThese findings indicate that the PVNCRH→DMVChAT pathway may mediate at least some aspects of GD related gastric motility, and provide new insights into the mechanisms by which somatic stimulation modulates the physiological functions of internal organs and systems.https://www.frontiersin.org/articles/10.3389/fnins.2023.1069198/fullgastric motility disordersneural circuitparaventricular nucleus of the hypothalamusdorsal motor nucleus of the vaguscorticotropin-releasing hormone |
| spellingShingle | Xi-yang Wang Xiao-qi Chen Guo-quan Wang Rong-lin Cai Hao Wang Hai-tao Wang Xiao-qi Peng Meng-ting Zhang Shun Huang Guo-ming Shen Guo-ming Shen A neural circuit for gastric motility disorders driven by gastric dilation in mice Frontiers in Neuroscience gastric motility disorders neural circuit paraventricular nucleus of the hypothalamus dorsal motor nucleus of the vagus corticotropin-releasing hormone |
| title | A neural circuit for gastric motility disorders driven by gastric dilation in mice |
| title_full | A neural circuit for gastric motility disorders driven by gastric dilation in mice |
| title_fullStr | A neural circuit for gastric motility disorders driven by gastric dilation in mice |
| title_full_unstemmed | A neural circuit for gastric motility disorders driven by gastric dilation in mice |
| title_short | A neural circuit for gastric motility disorders driven by gastric dilation in mice |
| title_sort | neural circuit for gastric motility disorders driven by gastric dilation in mice |
| topic | gastric motility disorders neural circuit paraventricular nucleus of the hypothalamus dorsal motor nucleus of the vagus corticotropin-releasing hormone |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1069198/full |
| work_keys_str_mv | AT xiyangwang aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT xiaoqichen aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT guoquanwang aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT ronglincai aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT haowang aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT haitaowang aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT xiaoqipeng aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT mengtingzhang aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT shunhuang aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT guomingshen aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT guomingshen aneuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT xiyangwang neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT xiaoqichen neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT guoquanwang neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT ronglincai neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT haowang neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT haitaowang neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT xiaoqipeng neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT mengtingzhang neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT shunhuang neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT guomingshen neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice AT guomingshen neuralcircuitforgastricmotilitydisordersdrivenbygastricdilationinmice |