Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model.
Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5874005?pdf=render |
| _version_ | 1819268046209941504 |
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| author | Geraint P Williams Benjamin Wu Yu Chi Liu Ericia Teo Chan L Nyein Gary Peh Donald T Tan Jodhbir S Mehta |
| author_facet | Geraint P Williams Benjamin Wu Yu Chi Liu Ericia Teo Chan L Nyein Gary Peh Donald T Tan Jodhbir S Mehta |
| author_sort | Geraint P Williams |
| collection | DOAJ |
| description | Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (<1.4D of intended), but a greater tendency to regression in +2D lenticule reimplantation. Central corneal thickness showed greater variation at +2D treatment, but central thickening during lenticule reimplantation at +4D treatment was seen (-17± 27μm LASIK, -45 ± 18μm SMILE and 28 ± 17μm Re-implantation; p <0.01) with expected paracentral thinning following SMILE. Although in vivo confocal microscopy appeared to show higher reflectivity in all +4D treatment groups, there were minimal and inconsistent changes in inflammatory responses between modalities. SMILE and lenticule re-implantation may represent a safe and viable method for treating hyperopia, but further optimization for lower hyperopic treatments is warranted. |
| first_indexed | 2024-12-23T21:26:50Z |
| format | Article |
| id | doaj.art-979176684305494b814b772543cfa1d5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T21:26:50Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-979176684305494b814b772543cfa1d52022-12-21T17:30:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01133e019420910.1371/journal.pone.0194209Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model.Geraint P WilliamsBenjamin WuYu Chi LiuEricia TeoChan L NyeinGary PehDonald T TanJodhbir S MehtaHyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (<1.4D of intended), but a greater tendency to regression in +2D lenticule reimplantation. Central corneal thickness showed greater variation at +2D treatment, but central thickening during lenticule reimplantation at +4D treatment was seen (-17± 27μm LASIK, -45 ± 18μm SMILE and 28 ± 17μm Re-implantation; p <0.01) with expected paracentral thinning following SMILE. Although in vivo confocal microscopy appeared to show higher reflectivity in all +4D treatment groups, there were minimal and inconsistent changes in inflammatory responses between modalities. SMILE and lenticule re-implantation may represent a safe and viable method for treating hyperopia, but further optimization for lower hyperopic treatments is warranted.http://europepmc.org/articles/PMC5874005?pdf=render |
| spellingShingle | Geraint P Williams Benjamin Wu Yu Chi Liu Ericia Teo Chan L Nyein Gary Peh Donald T Tan Jodhbir S Mehta Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model. PLoS ONE |
| title | Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model. |
| title_full | Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model. |
| title_fullStr | Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model. |
| title_full_unstemmed | Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model. |
| title_short | Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model. |
| title_sort | hyperopic refractive correction by lasik smile or lenticule reimplantation in a non human primate model |
| url | http://europepmc.org/articles/PMC5874005?pdf=render |
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