A novel biomarker in acute cholecystitis: YKL-40
Background: The lack of a specific biomarker that can be used in the diagnosis of acute cholecystitis, a common cause of admission to the emergency department, delays physician efforts to diagnose and treat these patients. Therefore, the aim of this study was to measure plasma YKL-40 levels and inve...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958422013318 |
| _version_ | 1827975336915107840 |
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| author | Eray Çeliktürk Ömer Salt Mustafa Burak Sayhan İlker Dıbırdık |
| author_facet | Eray Çeliktürk Ömer Salt Mustafa Burak Sayhan İlker Dıbırdık |
| author_sort | Eray Çeliktürk |
| collection | DOAJ |
| description | Background: The lack of a specific biomarker that can be used in the diagnosis of acute cholecystitis, a common cause of admission to the emergency department, delays physician efforts to diagnose and treat these patients. Therefore, the aim of this study was to measure plasma YKL-40 levels and investigate their diagnostic value in patients with acute cholecystitis (AC). Methods: This study was carried out between February 2020 and September 2020 in the adult emergency department of a tertiary university hospital. Permission was obtained from the Ethics Committee of Scientific Research on 03/02/2020 with Decision No. 03/16. The study included 80 patients who were diagnosed with acute cholecystitis and 80 healthy volunteers without known chronic diseases. Results: The median YKL-40 protein level was 798.66 pq/mL in the patient group and 392.45 pq/mL in the control group. A statistically significant difference in YKL-40 protein levels was found between the two groups. YKL-40 protein levels were significantly higher in patients diagnosed with acute cholecystitis than in healthy individuals (p < 0.001). A positive correlation was found between YKL-40 protein levels and ALT, AST, LDH, and GGT levels (r = 0.272, p = 0.015; r = 0.397, p < 0.001; r = 0.386, p < 0.001; and r = 0.264, p = 0.018; respectively). Conclusion: When evaluated together with physical examination, radiological imaging and other laboratory parameters, we think that plasma YKL-40 levels can be used effectively in the diagnosis of acute cholecystitis. |
| first_indexed | 2024-04-09T20:09:59Z |
| format | Article |
| id | doaj.art-97953c4a15f5401bad3b76ace0319592 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-04-09T20:09:59Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-97953c4a15f5401bad3b76ace03195922023-04-01T08:43:49ZengElsevierAsian Journal of Surgery1015-95842023-04-0146415641570A novel biomarker in acute cholecystitis: YKL-40Eray Çeliktürk0Ömer Salt1Mustafa Burak Sayhan2İlker Dıbırdık3Department of Emergency Medicine, Edirne Sultan 1. Murat State Hospital, Edirne, Turkey; Corresponding author. Emergency Physician Department of Emergency Department, Edirne Sultan 1. Murat State Hospital Edirne, 22030, Turkey.Department of Emergency Medicine, Trakya University Medicine Faculty, Edirne, TurkeyDepartment of Emergency Medicine, Trakya University Medicine Faculty, Edirne, TurkeyDepartment of Medical Biochemistry, Trakya University Medicine Faculty, Edirne, TurkeyBackground: The lack of a specific biomarker that can be used in the diagnosis of acute cholecystitis, a common cause of admission to the emergency department, delays physician efforts to diagnose and treat these patients. Therefore, the aim of this study was to measure plasma YKL-40 levels and investigate their diagnostic value in patients with acute cholecystitis (AC). Methods: This study was carried out between February 2020 and September 2020 in the adult emergency department of a tertiary university hospital. Permission was obtained from the Ethics Committee of Scientific Research on 03/02/2020 with Decision No. 03/16. The study included 80 patients who were diagnosed with acute cholecystitis and 80 healthy volunteers without known chronic diseases. Results: The median YKL-40 protein level was 798.66 pq/mL in the patient group and 392.45 pq/mL in the control group. A statistically significant difference in YKL-40 protein levels was found between the two groups. YKL-40 protein levels were significantly higher in patients diagnosed with acute cholecystitis than in healthy individuals (p < 0.001). A positive correlation was found between YKL-40 protein levels and ALT, AST, LDH, and GGT levels (r = 0.272, p = 0.015; r = 0.397, p < 0.001; r = 0.386, p < 0.001; and r = 0.264, p = 0.018; respectively). Conclusion: When evaluated together with physical examination, radiological imaging and other laboratory parameters, we think that plasma YKL-40 levels can be used effectively in the diagnosis of acute cholecystitis.http://www.sciencedirect.com/science/article/pii/S1015958422013318Acute cholecystitisEmergency medicineYKL-40 |
| spellingShingle | Eray Çeliktürk Ömer Salt Mustafa Burak Sayhan İlker Dıbırdık A novel biomarker in acute cholecystitis: YKL-40 Asian Journal of Surgery Acute cholecystitis Emergency medicine YKL-40 |
| title | A novel biomarker in acute cholecystitis: YKL-40 |
| title_full | A novel biomarker in acute cholecystitis: YKL-40 |
| title_fullStr | A novel biomarker in acute cholecystitis: YKL-40 |
| title_full_unstemmed | A novel biomarker in acute cholecystitis: YKL-40 |
| title_short | A novel biomarker in acute cholecystitis: YKL-40 |
| title_sort | novel biomarker in acute cholecystitis ykl 40 |
| topic | Acute cholecystitis Emergency medicine YKL-40 |
| url | http://www.sciencedirect.com/science/article/pii/S1015958422013318 |
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