A phosphodiesterase 4-controlled switch between memory extinction and strengthening in the hippocampus

A phosphodiesterase 4-controlled switch between memory extinction and strengthening in the hippocampus

Established fear-related memories can undergo phenomena such as extinction or reconsolidation when recalled. Extinction probably involves the creation of a new, competing memory trace that decreases fear expression, whereas reconsolidation can mediate memory maintenance, updating, or strengthening....

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Bibliographic Details
Main Authors: Rafael eRoesler, Gustavo Kellermann Reolon, Natasha eMaurmann, Gilberto eSchwartsmann, Nadja eSchröder, Olavo Bohrer Amaral, Samira eValvassori, João eQuevedo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Hippocampus
Rolipram
extinction
reconsolidation
fear memory
Inhibitory avoidance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00091/full

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