Antisense Oligonucleotides Used to Identify Telomeric G-Quadruplexes in Metaphase Chromosomes and Fixed Cells by Fluorescence Lifetime Imaging Microscopy of <i>o</i>-BMVC Foci

Antisense Oligonucleotides Used to Identify Telomeric G-Quadruplexes in Metaphase Chromosomes and Fixed Cells by Fluorescence Lifetime Imaging Microscopy of <i>o</i>-BMVC Foci

Identification of the existence of G-quadruplex (G4) structure, from a specific G-rich sequence in cells, is critical to the studies of structural biology and drug development. Accumulating evidence supports the existence of G4 structure in vivo. Particularly, time-gated fluorescence lifetime imagin...

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Bibliographic Details
Main Authors: Ting-Yuan Tseng, Shin-Ya Liu, Chiung-Lin Wang, Ta-Chau Chang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
G-quadruplex
telomeric G4 structure
antisense oligonucleotide
fluorescence lifetime imaging microscopy
<i>o</i>-BMVC foci
Online Access:https://www.mdpi.com/1420-3049/25/18/4083

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