Breast milk microRNAs: Potential players in oral tolerance development
Breast milk is an essential source of nutrition and hydration for the infant. In addition, this highly complex biological fluid contains numerous immunologically active factors such as microorganisms, immunoglobulins, cytokines and microRNAs (miRNAs). Here, we set out to predict the function of the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154211/full |
| _version_ | 1797871444134199296 |
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| author | Emelie Ahlberg Ahmed Al-Kaabawi Rebecka Thune Melanie Rae Simpson Sindre Andre Pedersen Erika Cione Maria Christina Jenmalm Lina Tingö Lina Tingö Lina Tingö |
| author_facet | Emelie Ahlberg Ahmed Al-Kaabawi Rebecka Thune Melanie Rae Simpson Sindre Andre Pedersen Erika Cione Maria Christina Jenmalm Lina Tingö Lina Tingö Lina Tingö |
| author_sort | Emelie Ahlberg |
| collection | DOAJ |
| description | Breast milk is an essential source of nutrition and hydration for the infant. In addition, this highly complex biological fluid contains numerous immunologically active factors such as microorganisms, immunoglobulins, cytokines and microRNAs (miRNAs). Here, we set out to predict the function of the top 10 expressed miRNAs in human breast milk, focusing on their relevance in oral tolerance development and allergy prevention in the infant. The top expressed miRNAs in human breast milk were identified on basis of previous peer-reviewed studies gathered from a recent systematic review and an updated literature search. The miRNAs with the highest expression levels in each study were used to identify the 10 most common miRNAs or miRNA families across studies and these were selected for subsequent target prediction. The predictions were performed using TargetScan in combination with the Database for Annotation, Visualization and Integrated Discovery. The ten top expressed miRNAs were: let-7-5p family, miR-148a-3p, miR-30-5p family, miR-200a-3p + miR-141-3p, miR-22-3p, miR-181-5p family, miR-146b-5p, miR-378a-3p, miR-29-3p family, miR-200b/c-3p and miR-429-3p. The target prediction identified 3,588 potential target genes and 127 Kyoto Encyclopedia of Genes and Genomes pathways; several connected to the immune system, including TGF-b and T cell receptor signaling and T-helper cell differentiation. This review highlights the role of breast milk miRNAs and their potential contribution to infant immune maturation. Indeed, breast milk miRNAs seem to be involved in several pathways that influence oral tolerance development. |
| first_indexed | 2024-04-10T00:43:05Z |
| format | Article |
| id | doaj.art-979c77cccdec4531923c4f191000589e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T00:43:05Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-979c77cccdec4531923c4f191000589e2023-03-14T04:55:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11542111154211Breast milk microRNAs: Potential players in oral tolerance developmentEmelie Ahlberg0Ahmed Al-Kaabawi1Rebecka Thune2Melanie Rae Simpson3Sindre Andre Pedersen4Erika Cione5Maria Christina Jenmalm6Lina Tingö7Lina Tingö8Lina Tingö9Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenDepartment of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayLibrary Section for Research Support, Data and Analysis, NTNU University Library, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, ItalyDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenNutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Örebro University, Örebro, SwedenFood and Health Programme, Örebro University, Örebro, SwedenBreast milk is an essential source of nutrition and hydration for the infant. In addition, this highly complex biological fluid contains numerous immunologically active factors such as microorganisms, immunoglobulins, cytokines and microRNAs (miRNAs). Here, we set out to predict the function of the top 10 expressed miRNAs in human breast milk, focusing on their relevance in oral tolerance development and allergy prevention in the infant. The top expressed miRNAs in human breast milk were identified on basis of previous peer-reviewed studies gathered from a recent systematic review and an updated literature search. The miRNAs with the highest expression levels in each study were used to identify the 10 most common miRNAs or miRNA families across studies and these were selected for subsequent target prediction. The predictions were performed using TargetScan in combination with the Database for Annotation, Visualization and Integrated Discovery. The ten top expressed miRNAs were: let-7-5p family, miR-148a-3p, miR-30-5p family, miR-200a-3p + miR-141-3p, miR-22-3p, miR-181-5p family, miR-146b-5p, miR-378a-3p, miR-29-3p family, miR-200b/c-3p and miR-429-3p. The target prediction identified 3,588 potential target genes and 127 Kyoto Encyclopedia of Genes and Genomes pathways; several connected to the immune system, including TGF-b and T cell receptor signaling and T-helper cell differentiation. This review highlights the role of breast milk miRNAs and their potential contribution to infant immune maturation. Indeed, breast milk miRNAs seem to be involved in several pathways that influence oral tolerance development.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154211/fullmicro-RNAnon-coding RNAdendritic cellsoral toleranceregulatory T cellallergy |
| spellingShingle | Emelie Ahlberg Ahmed Al-Kaabawi Rebecka Thune Melanie Rae Simpson Sindre Andre Pedersen Erika Cione Maria Christina Jenmalm Lina Tingö Lina Tingö Lina Tingö Breast milk microRNAs: Potential players in oral tolerance development Frontiers in Immunology micro-RNA non-coding RNA dendritic cells oral tolerance regulatory T cell allergy |
| title | Breast milk microRNAs: Potential players in oral tolerance development |
| title_full | Breast milk microRNAs: Potential players in oral tolerance development |
| title_fullStr | Breast milk microRNAs: Potential players in oral tolerance development |
| title_full_unstemmed | Breast milk microRNAs: Potential players in oral tolerance development |
| title_short | Breast milk microRNAs: Potential players in oral tolerance development |
| title_sort | breast milk micrornas potential players in oral tolerance development |
| topic | micro-RNA non-coding RNA dendritic cells oral tolerance regulatory T cell allergy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154211/full |
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