Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma
Purpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studie...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2020-08-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1938 |
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| author | I. V. Goroncharovskaya A. K. Evseev A. K. Shabanov V. V. Kulabukhov A. N. Kuzovlev K. A. Popugaev S. S. Petrikov |
| author_facet | I. V. Goroncharovskaya A. K. Evseev A. K. Shabanov V. V. Kulabukhov A. N. Kuzovlev K. A. Popugaev S. S. Petrikov |
| author_sort | I. V. Goroncharovskaya |
| collection | DOAJ |
| description | Purpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studied in 35 patients with severe combined trauma and 35 post-FFP samples with at least 6-month shelf life. The electrochemical parameters of patients’ blood plasma were analyzed before transfusion, and 1 hr. and 24 hrs. after transfusion.Results. OCP measured in FFP was found to be more positive vs. OCP measured in recipients' blood plasma in 34 out of 35 cases (97%). It has been shown that in patients with severe combined trauma, OCP increased from 5.047 [-7.553; 12.976] mV to 12.827 [-1.372; 24.764] mV and antioxidant activity decreased 24 hours after FFP transfusion from 16.979 [11.302; 20.946] µC to 13.551 [9.288; 18.405] µC. After FFP transfusion, there were no significant changes in clinical blood parameters.Conclusion. By measuring electrochemical parameters of blood plasma in patients with severe combined trauma before and after FFP transfusions, it was discovered that in spite of absence of changes in blood parameters by routine methods, there are changes in the condition of the antioxidant system of the body, which manifest in the bias of patients’ blood plasma OCP towards higher positive values and decreased antioxidant activity. Redox imbalance in the body might cause the oxidative stress development. |
| first_indexed | 2024-04-10T01:27:21Z |
| format | Article |
| id | doaj.art-979f2921ae30474081f0c104585fcc2c |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:27:21Z |
| publishDate | 2020-08-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-979f2921ae30474081f0c104585fcc2c2023-03-13T09:32:56ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102020-08-0116441310.15360/1813-9779-2020-4-4-131749Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined TraumaI. V. Goroncharovskaya0A. K. Evseev1A. K. Shabanov2V. V. Kulabukhov3A. N. Kuzovlev4K. A. Popugaev5S. S. Petrikov6НИИ скорой помощи им. Н. В. Склифосовского ДЗМНИИ скорой помощи им. Н. В. Склифосовского ДЗМНИИ скорой помощи им. Н. В. Склифосовского ДЗМ; НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РРНИИ скорой помощи им. Н. В. Склифосовского ДЗМНИИ общей реаниматологии им. В. А. Неговского ФНКЦ РРНИИ скорой помощи им. Н. В. Склифосовского ДЗМНИИ скорой помощи им. Н. В. Склифосовского ДЗМPurpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studied in 35 patients with severe combined trauma and 35 post-FFP samples with at least 6-month shelf life. The electrochemical parameters of patients’ blood plasma were analyzed before transfusion, and 1 hr. and 24 hrs. after transfusion.Results. OCP measured in FFP was found to be more positive vs. OCP measured in recipients' blood plasma in 34 out of 35 cases (97%). It has been shown that in patients with severe combined trauma, OCP increased from 5.047 [-7.553; 12.976] mV to 12.827 [-1.372; 24.764] mV and antioxidant activity decreased 24 hours after FFP transfusion from 16.979 [11.302; 20.946] µC to 13.551 [9.288; 18.405] µC. After FFP transfusion, there were no significant changes in clinical blood parameters.Conclusion. By measuring electrochemical parameters of blood plasma in patients with severe combined trauma before and after FFP transfusions, it was discovered that in spite of absence of changes in blood parameters by routine methods, there are changes in the condition of the antioxidant system of the body, which manifest in the bias of patients’ blood plasma OCP towards higher positive values and decreased antioxidant activity. Redox imbalance in the body might cause the oxidative stress development.https://www.reanimatology.com/rmt/article/view/1938потенциал при разомкнутой цепиплатиновый электродтрансфузияанти- оксидантная активностьтяжелая сочетанная травмаплазма крови |
| spellingShingle | I. V. Goroncharovskaya A. K. Evseev A. K. Shabanov V. V. Kulabukhov A. N. Kuzovlev K. A. Popugaev S. S. Petrikov Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma Общая реаниматология потенциал при разомкнутой цепи платиновый электрод трансфузия анти- оксидантная активность тяжелая сочетанная травма плазма крови |
| title | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_full | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_fullStr | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_full_unstemmed | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_short | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_sort | effect of fresh frozen plasma transfusion on electrochemical parameters of blood plasma in patients with severe combined trauma |
| topic | потенциал при разомкнутой цепи платиновый электрод трансфузия анти- оксидантная активность тяжелая сочетанная травма плазма крови |
| url | https://www.reanimatology.com/rmt/article/view/1938 |
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