Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its ce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2021-11-01
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| Series: | Vascular Biology |
| Subjects: | |
| Online Access: | https://vb.bioscientifica.com/view/journals/vb/3/1/VB-21-0013.xml |
| _version_ | 1818754339968122880 |
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| author | Marie Mclaughlin Geraint Florida-James Mark Ross |
| author_facet | Marie Mclaughlin Geraint Florida-James Mark Ross |
| author_sort | Marie Mclaughlin |
| collection | DOAJ |
| description | Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its central importance within the cardiovascular system and resultant detrimental effects of damage and dysfunction. This review highlights the impact of chemotherapy for breast cancer on the vascular endothelium. We consider the most likely mechanisms of endothelial toxicity to be through direct damage and dysfunction of the endothelium. There are sharp consequences of these detrimental effects as they can lead to cardiovascular disease. However, there is potential for exercise to alleviate some of the vascular toxicity of chemotherapy, and the evidence for this is provided. The potential role of exercise in protecting against vascular toxicity is explained, highlighting the recent in-human and animal model exercise interventions. Lastly, the mediating mechanisms of exercise protection of endothelial health is discussed, focusing on the importance of exercise for endothelial health, function, repair, inflammation and hyperlipidaemia, angiogenesis, and vascular remodelling. These are all important counteracting measures against chemotherapy-induced toxicity and are discussed in detail. |
| first_indexed | 2024-12-18T05:21:41Z |
| format | Article |
| id | doaj.art-97a1e5cf09584e95a643d32dea50f647 |
| institution | Directory Open Access Journal |
| issn | 2516-5658 |
| language | English |
| last_indexed | 2024-12-18T05:21:41Z |
| publishDate | 2021-11-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Vascular Biology |
| spelling | doaj.art-97a1e5cf09584e95a643d32dea50f6472022-12-21T21:19:38ZengBioscientificaVascular Biology2516-56582021-11-0131R106R120https://doi.org/10.1530/VB-21-0013Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeuticMarie Mclaughlin0Geraint Florida-James1Mark Ross2School of Applied Sciences, Edinburgh Napier University, Edinburgh, UKSchool of Applied Sciences, Edinburgh Napier University, Edinburgh, UKSchool of Applied Sciences, Edinburgh Napier University, Edinburgh, UKBreast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its central importance within the cardiovascular system and resultant detrimental effects of damage and dysfunction. This review highlights the impact of chemotherapy for breast cancer on the vascular endothelium. We consider the most likely mechanisms of endothelial toxicity to be through direct damage and dysfunction of the endothelium. There are sharp consequences of these detrimental effects as they can lead to cardiovascular disease. However, there is potential for exercise to alleviate some of the vascular toxicity of chemotherapy, and the evidence for this is provided. The potential role of exercise in protecting against vascular toxicity is explained, highlighting the recent in-human and animal model exercise interventions. Lastly, the mediating mechanisms of exercise protection of endothelial health is discussed, focusing on the importance of exercise for endothelial health, function, repair, inflammation and hyperlipidaemia, angiogenesis, and vascular remodelling. These are all important counteracting measures against chemotherapy-induced toxicity and are discussed in detail.https://vb.bioscientifica.com/view/journals/vb/3/1/VB-21-0013.xmlchemotherapycardiovascular toxicityvasculo-oncologyendotheliumexercisecardio-oncology |
| spellingShingle | Marie Mclaughlin Geraint Florida-James Mark Ross Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic Vascular Biology chemotherapy cardiovascular toxicity vasculo-oncology endothelium exercise cardio-oncology |
| title | Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic |
| title_full | Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic |
| title_fullStr | Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic |
| title_full_unstemmed | Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic |
| title_short | Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic |
| title_sort | breast cancer chemotherapy vascular toxicity a review of mediating mechanisms and exercise as a potential therapeutic |
| topic | chemotherapy cardiovascular toxicity vasculo-oncology endothelium exercise cardio-oncology |
| url | https://vb.bioscientifica.com/view/journals/vb/3/1/VB-21-0013.xml |
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