A placebo-controlled Bayesian dose finding design based on continuous reassessment method with application to stroke research

A placebo-controlled Bayesian dose finding design based on continuous reassessment method with application to stroke research

Traditional dose-finding designs do not require assignment of patients to a control group. Motivated by SHRINC (Safety of Pioglitazone for hematoma resolution in intracerebral hemorrhage), we developed a placebo-controlled dose-finding study to identify the maximum tolerated dose for pioglitazone in...

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Bibliographic Details
Main Authors: Chunyan Cai, Mohammad H. Rahbar, Md Monir Hossain, Ying Yuan, Nicole R. Gonzales
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865416300898

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