Chemical toxic exposures and chronic ocular pain
Chronic ocular pain is a common, debilitating chronic pain condition with significant morbidity and negative impact in patients’ quality of life. Several, diverse types of insults to the ocular surface can lead to acute, and under certain conditions to chronic ocular pain, and these include toxic ir...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Toxicology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2023.1188152/full |
| _version_ | 1797745767021019136 |
|---|---|
| author | Mateusz Graca Konstantinos Sarantopoulos Danielle Bodzin Horn |
| author_facet | Mateusz Graca Konstantinos Sarantopoulos Danielle Bodzin Horn |
| author_sort | Mateusz Graca |
| collection | DOAJ |
| description | Chronic ocular pain is a common, debilitating chronic pain condition with significant morbidity and negative impact in patients’ quality of life. Several, diverse types of insults to the ocular surface can lead to acute, and under certain conditions to chronic ocular pain, and these include toxic irritants. Exposure of ocular surface to toxic irritants, in addition to direct tissue injury, carries the capacity to generated intense immune and neuronal responses with hyper-excitability, sensitization and chronic pain. Because, chronic ocular pain subsequent to toxic exposures is relatively unrecognized clinical entity, this brief review highlights pertinent concepts of its epidemiology, pathogenesis/pathophysiology, clinical progression, with recommendations for its clinical management that clinicians may find helpful. Suppression of pain signaling, generating neuronal sensitization, and prevention of chronicity of neuropathic pain is particularly emphasized in this respect. |
| first_indexed | 2024-03-12T15:27:43Z |
| format | Article |
| id | doaj.art-97a4d35345fa4f1894a758b98dc2c618 |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-03-12T15:27:43Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-97a4d35345fa4f1894a758b98dc2c6182023-08-10T11:49:04ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802023-08-01510.3389/ftox.2023.11881521188152Chemical toxic exposures and chronic ocular painMateusz Graca0Konstantinos Sarantopoulos1Danielle Bodzin Horn2Department of Anesthesiology, Rush University Medical Center, Chicago, IL, United StatesDepartment of Anesthesiology, Perioperative Medicine and Pain Medicine, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Anesthesiology, Perioperative Medicine and Pain Medicine, University of Miami Miller School of Medicine, Miami, FL, United StatesChronic ocular pain is a common, debilitating chronic pain condition with significant morbidity and negative impact in patients’ quality of life. Several, diverse types of insults to the ocular surface can lead to acute, and under certain conditions to chronic ocular pain, and these include toxic irritants. Exposure of ocular surface to toxic irritants, in addition to direct tissue injury, carries the capacity to generated intense immune and neuronal responses with hyper-excitability, sensitization and chronic pain. Because, chronic ocular pain subsequent to toxic exposures is relatively unrecognized clinical entity, this brief review highlights pertinent concepts of its epidemiology, pathogenesis/pathophysiology, clinical progression, with recommendations for its clinical management that clinicians may find helpful. Suppression of pain signaling, generating neuronal sensitization, and prevention of chronicity of neuropathic pain is particularly emphasized in this respect.https://www.frontiersin.org/articles/10.3389/ftox.2023.1188152/fullchemical injurytoxicityocular surfacecorneaocular pain |
| spellingShingle | Mateusz Graca Konstantinos Sarantopoulos Danielle Bodzin Horn Chemical toxic exposures and chronic ocular pain Frontiers in Toxicology chemical injury toxicity ocular surface cornea ocular pain |
| title | Chemical toxic exposures and chronic ocular pain |
| title_full | Chemical toxic exposures and chronic ocular pain |
| title_fullStr | Chemical toxic exposures and chronic ocular pain |
| title_full_unstemmed | Chemical toxic exposures and chronic ocular pain |
| title_short | Chemical toxic exposures and chronic ocular pain |
| title_sort | chemical toxic exposures and chronic ocular pain |
| topic | chemical injury toxicity ocular surface cornea ocular pain |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2023.1188152/full |
| work_keys_str_mv | AT mateuszgraca chemicaltoxicexposuresandchronicocularpain AT konstantinossarantopoulos chemicaltoxicexposuresandchronicocularpain AT daniellebodzinhorn chemicaltoxicexposuresandchronicocularpain |