Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target

Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target

Loss or mutation of the tumour suppressor Merlin predisposes individuals to develop multiple nervous system tumours, including schwannomas and meningiomas, sporadically or as part of the autosomal dominant inherited condition Neurofibromatosis 2 (NF2). These tumours display largely low grade feature...

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Bibliographic Details
Main Authors: Kayleigh Bassiri, Sara Ferluga, Vikram Sharma, Nelofer Syed, Claire L. Adams, Edwin Lasonder, C Oliver Hanemann
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:EBioMedicine
Subjects:
Meningioma
Schwannoma
NF2
Merlin
Proteome
Phospho-proteome
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417300245

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