No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder
Pharmacoepigenetic studies are important to understand the mechanisms through which medications influence the developing fetus. For instance, we and others have reported associations between prenatal paracetamol exposure and offspring DNA methylation (DNAm). Additionally, folic acid (FA) intake duri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1204879/full |
| _version_ | 1797803808707837952 |
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| author | Emilie Willoch Olstad Emilie Willoch Olstad Hedvig Marie Egeland Nordeng Hedvig Marie Egeland Nordeng Hedvig Marie Egeland Nordeng Robert Lyle Robert Lyle Robert Lyle Kristina Gervin Kristina Gervin Kristina Gervin |
| author_facet | Emilie Willoch Olstad Emilie Willoch Olstad Hedvig Marie Egeland Nordeng Hedvig Marie Egeland Nordeng Hedvig Marie Egeland Nordeng Robert Lyle Robert Lyle Robert Lyle Kristina Gervin Kristina Gervin Kristina Gervin |
| author_sort | Emilie Willoch Olstad |
| collection | DOAJ |
| description | Pharmacoepigenetic studies are important to understand the mechanisms through which medications influence the developing fetus. For instance, we and others have reported associations between prenatal paracetamol exposure and offspring DNA methylation (DNAm). Additionally, folic acid (FA) intake during pregnancy has been associated with DNAm in genes linked to developmental abnormalities. In this study, we aimed to: (i) expand on our previous findings showing differential DNAm associated with long-term prenatal paracetamol exposure in offspring with attention-deficit/hyperactivity disorder (ADHD), and (ii) examine if there is an interaction effect of FA and paracetamol on DNAm in children with ADHD. We used data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN). We did not identify any impact of paracetamol or any interaction effect of paracetamol and FA on cord blood DNAm in children with ADHD. Our results contribute to the growing literature on prenatal pharmacoepigenetics, but should be replicated in other cohorts. Replication of pharmacoepigenetic studies is essential to ensure robust findings and to increase the clinical relevance of such studies. |
| first_indexed | 2024-03-13T05:26:37Z |
| format | Article |
| id | doaj.art-97a827b8a7d246449b5bb2438892da37 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-13T05:26:37Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-97a827b8a7d246449b5bb2438892da372023-06-15T05:41:10ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-06-011410.3389/fgene.2023.12048791204879No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorderEmilie Willoch Olstad0Emilie Willoch Olstad1Hedvig Marie Egeland Nordeng2Hedvig Marie Egeland Nordeng3Hedvig Marie Egeland Nordeng4Robert Lyle5Robert Lyle6Robert Lyle7Kristina Gervin8Kristina Gervin9Kristina Gervin10Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, NorwayPharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, NorwayPharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, NorwayPharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, NorwayDepartment of Child Health and Development, Norwegian Institute of Public Health, Oslo, NorwayPharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, NorwayDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, NorwayCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, NorwayPharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, NorwayPharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, NorwayDepartment of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, NorwayPharmacoepigenetic studies are important to understand the mechanisms through which medications influence the developing fetus. For instance, we and others have reported associations between prenatal paracetamol exposure and offspring DNA methylation (DNAm). Additionally, folic acid (FA) intake during pregnancy has been associated with DNAm in genes linked to developmental abnormalities. In this study, we aimed to: (i) expand on our previous findings showing differential DNAm associated with long-term prenatal paracetamol exposure in offspring with attention-deficit/hyperactivity disorder (ADHD), and (ii) examine if there is an interaction effect of FA and paracetamol on DNAm in children with ADHD. We used data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN). We did not identify any impact of paracetamol or any interaction effect of paracetamol and FA on cord blood DNAm in children with ADHD. Our results contribute to the growing literature on prenatal pharmacoepigenetics, but should be replicated in other cohorts. Replication of pharmacoepigenetic studies is essential to ensure robust findings and to increase the clinical relevance of such studies.https://www.frontiersin.org/articles/10.3389/fgene.2023.1204879/fullADHD (attention deficit and hyperactivity disorder)DNA methyaltionEWAS, epigenome wide association studyfolic acid (FA)MoBa (norwegian mother and child cohort study)paracetamol |
| spellingShingle | Emilie Willoch Olstad Emilie Willoch Olstad Hedvig Marie Egeland Nordeng Hedvig Marie Egeland Nordeng Hedvig Marie Egeland Nordeng Robert Lyle Robert Lyle Robert Lyle Kristina Gervin Kristina Gervin Kristina Gervin No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder Frontiers in Genetics ADHD (attention deficit and hyperactivity disorder) DNA methyaltion EWAS, epigenome wide association study folic acid (FA) MoBa (norwegian mother and child cohort study) paracetamol |
| title | No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder |
| title_full | No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder |
| title_fullStr | No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder |
| title_full_unstemmed | No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder |
| title_short | No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder |
| title_sort | no impact of prenatal paracetamol and folic acid exposure on cord blood dna methylation in children with attention deficit hyperactivity disorder |
| topic | ADHD (attention deficit and hyperactivity disorder) DNA methyaltion EWAS, epigenome wide association study folic acid (FA) MoBa (norwegian mother and child cohort study) paracetamol |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1204879/full |
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