Diffuse B-cell lymphoma in a child with HIV infection
Objective. To describe the case of diffuse B-cell lymphoma in a child with HIV infection.Results. A 16-year-old child with HIV infection and generalized lymphadenopathy was diagnosed with diffuse large B-cell lymphoma, stage III, negative central nervous system. The patient was diagnosed on the basi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2021-12-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1507 |
| _version_ | 1797875115428413440 |
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| author | Kh. S. Khaertynov V. A. Anokhin S. V. Khaliullina I. V. Osipova V. Yu. Shapiro S. V. Petrov I. G. Idrisov A. Kh. Bulatova Yu. A. Raimova |
| author_facet | Kh. S. Khaertynov V. A. Anokhin S. V. Khaliullina I. V. Osipova V. Yu. Shapiro S. V. Petrov I. G. Idrisov A. Kh. Bulatova Yu. A. Raimova |
| author_sort | Kh. S. Khaertynov |
| collection | DOAJ |
| description | Objective. To describe the case of diffuse B-cell lymphoma in a child with HIV infection.Results. A 16-year-old child with HIV infection and generalized lymphadenopathy was diagnosed with diffuse large B-cell lymphoma, stage III, negative central nervous system. The patient was diagnosed on the basis of the results of immunohistochemical study of biopaths of the tissue of the lymph nodes of the submandibular and right axillary region. The study in order to identify markers of active infection caused by the Epstein-Barr virus, cytomegalovirus and human herpesvirus type 6, made it possible to exclude the active phase of diseases that are the main infectious causes of lymphoproliferative syndrome. At the time of hospitalization, the patient was treated with antiretroviral therapy of the combined drug Eviplera. There was no HIV RNA in the blood, the level of CD4 lymphocytes was 0.4·109/l. The BFM chemotherapy regimen was used, which was accompanied by positive dynamics in the form of normalization of body temperature, reduction in the size of lymph nodes.Conclusion. This case shows that immunohistochemical examination of tissue biopsies of enlarged lymph nodes is of decisive importance in the diagnosis of lymphoma, the main non-infectious cause of lymphoproliferative syndrome in patients with HIV infection. |
| first_indexed | 2024-04-10T01:42:32Z |
| format | Article |
| id | doaj.art-97a882b872f547b898a182b7541c3bcd |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:42:32Z |
| publishDate | 2021-12-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-97a882b872f547b898a182b7541c3bcd2023-03-13T09:12:51ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282021-12-0166521321810.21508/1027-4065-2021-66-5-213-2181120Diffuse B-cell lymphoma in a child with HIV infectionKh. S. Khaertynov0V. A. Anokhin1S. V. Khaliullina2I. V. Osipova3V. Yu. Shapiro4S. V. Petrov5I. G. Idrisov6A. Kh. Bulatova7Yu. A. Raimova8ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииГАУЗ «Детская республиканская клиническая больница» Минздрава Республики ТатарстанГАУЗ «Детская республиканская клиническая больница» Минздрава Республики ТатарстанФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииГАУЗ «Республиканская клиническая инфекционная больница им. профессора А.Ф. Агафонова»Казанская государственная медицинская академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииObjective. To describe the case of diffuse B-cell lymphoma in a child with HIV infection.Results. A 16-year-old child with HIV infection and generalized lymphadenopathy was diagnosed with diffuse large B-cell lymphoma, stage III, negative central nervous system. The patient was diagnosed on the basis of the results of immunohistochemical study of biopaths of the tissue of the lymph nodes of the submandibular and right axillary region. The study in order to identify markers of active infection caused by the Epstein-Barr virus, cytomegalovirus and human herpesvirus type 6, made it possible to exclude the active phase of diseases that are the main infectious causes of lymphoproliferative syndrome. At the time of hospitalization, the patient was treated with antiretroviral therapy of the combined drug Eviplera. There was no HIV RNA in the blood, the level of CD4 lymphocytes was 0.4·109/l. The BFM chemotherapy regimen was used, which was accompanied by positive dynamics in the form of normalization of body temperature, reduction in the size of lymph nodes.Conclusion. This case shows that immunohistochemical examination of tissue biopsies of enlarged lymph nodes is of decisive importance in the diagnosis of lymphoma, the main non-infectious cause of lymphoproliferative syndrome in patients with HIV infection.https://www.ped-perinatology.ru/jour/article/view/1507детивич-инфекцияв-клеточная лимфомаиммуногистохимия |
| spellingShingle | Kh. S. Khaertynov V. A. Anokhin S. V. Khaliullina I. V. Osipova V. Yu. Shapiro S. V. Petrov I. G. Idrisov A. Kh. Bulatova Yu. A. Raimova Diffuse B-cell lymphoma in a child with HIV infection Rossijskij Vestnik Perinatologii i Pediatrii дети вич-инфекция в-клеточная лимфома иммуногистохимия |
| title | Diffuse B-cell lymphoma in a child with HIV infection |
| title_full | Diffuse B-cell lymphoma in a child with HIV infection |
| title_fullStr | Diffuse B-cell lymphoma in a child with HIV infection |
| title_full_unstemmed | Diffuse B-cell lymphoma in a child with HIV infection |
| title_short | Diffuse B-cell lymphoma in a child with HIV infection |
| title_sort | diffuse b cell lymphoma in a child with hiv infection |
| topic | дети вич-инфекция в-клеточная лимфома иммуногистохимия |
| url | https://www.ped-perinatology.ru/jour/article/view/1507 |
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