The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019
Nonalcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The aging population and a rise in metabolic syndrome in Asia might influence the epidemiology of NAFLD among the elderly. However, there is a lack of understanding of the burden and recommendations for NAFLD...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/20/6456 |
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| author | Pojsakorn Danpanichkul Siwanart Kongarin Sarunpakorn Permpatdechakul Natchaya Polpichai Kwanjit Duangsonk Worapaka Manosroi Nathorn Chaiyakunapruk Omar Y. Mousa Donghee Kim Vincent L. Chen Karn Wijarnpreecha |
| author_facet | Pojsakorn Danpanichkul Siwanart Kongarin Sarunpakorn Permpatdechakul Natchaya Polpichai Kwanjit Duangsonk Worapaka Manosroi Nathorn Chaiyakunapruk Omar Y. Mousa Donghee Kim Vincent L. Chen Karn Wijarnpreecha |
| author_sort | Pojsakorn Danpanichkul |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The aging population and a rise in metabolic syndrome in Asia might influence the epidemiology of NAFLD among the elderly. However, there is a lack of understanding of the burden and recommendations for NAFLD in this group. Our study sought to investigate the trends in the NAFLD burden among the elderly in the Asia-Pacific region. We employed data from the Global Burden of Disease 2019 study for an in-depth analysis of the prevalence and disability-adjusted life years (DALYs) along with age-standardized rate (ASR) associated with NAFLD in elderly populations (age 65–89 years) across the Asia-Pacific region, including the Southeast Asia (SEA) and Western Pacific (WP) regions, from 2010 to 2019. This study also examined the trends and disparities in NAFLD burden across different nations and sexes. In 2019, there were over 120 million cases of NAFLD in the elderly in the Asia-Pacific region. The ASR of prevalence was higher in SEA compared to WP (36,995.37 vs. 32,821.78 per 100,000). ASR of prevalence increased with annual percentage change (APC) +0.95% in the WP while it increased by +0.87% in SEA. During the study period, the ASR of DALYs decreased in SEA (APC −0.41%) but remained stable in the WP region. The burden of NAFLD in the elderly population in Asia-Pacific has increased, underscoring the timely intervention to tackle this high and rising burden. |
| first_indexed | 2024-03-10T21:10:59Z |
| format | Article |
| id | doaj.art-97aa31e8eed440f6a9a6630676998983 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:10:59Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-97aa31e8eed440f6a9a66306769989832023-11-19T16:51:23ZengMDPI AGJournal of Clinical Medicine2077-03832023-10-011220645610.3390/jcm12206456The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019Pojsakorn Danpanichkul0Siwanart Kongarin1Sarunpakorn Permpatdechakul2Natchaya Polpichai3Kwanjit Duangsonk4Worapaka Manosroi5Nathorn Chaiyakunapruk6Omar Y. Mousa7Donghee Kim8Vincent L. Chen9Karn Wijarnpreecha10Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandFaculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandFaculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Internal Medicine, Weiss Memorial Hospital, Chicago, IL 60640, USADepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDivision of Endocrinology, Department of Internal Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USADivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Mayo Clinic Health System, Rochester, MN 55902, USADivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USADivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 41809, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ 85004, USANonalcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The aging population and a rise in metabolic syndrome in Asia might influence the epidemiology of NAFLD among the elderly. However, there is a lack of understanding of the burden and recommendations for NAFLD in this group. Our study sought to investigate the trends in the NAFLD burden among the elderly in the Asia-Pacific region. We employed data from the Global Burden of Disease 2019 study for an in-depth analysis of the prevalence and disability-adjusted life years (DALYs) along with age-standardized rate (ASR) associated with NAFLD in elderly populations (age 65–89 years) across the Asia-Pacific region, including the Southeast Asia (SEA) and Western Pacific (WP) regions, from 2010 to 2019. This study also examined the trends and disparities in NAFLD burden across different nations and sexes. In 2019, there were over 120 million cases of NAFLD in the elderly in the Asia-Pacific region. The ASR of prevalence was higher in SEA compared to WP (36,995.37 vs. 32,821.78 per 100,000). ASR of prevalence increased with annual percentage change (APC) +0.95% in the WP while it increased by +0.87% in SEA. During the study period, the ASR of DALYs decreased in SEA (APC −0.41%) but remained stable in the WP region. The burden of NAFLD in the elderly population in Asia-Pacific has increased, underscoring the timely intervention to tackle this high and rising burden.https://www.mdpi.com/2077-0383/12/20/6456steatotic liver diseaseelderlyAsiaepidemiologygeriatrics |
| spellingShingle | Pojsakorn Danpanichkul Siwanart Kongarin Sarunpakorn Permpatdechakul Natchaya Polpichai Kwanjit Duangsonk Worapaka Manosroi Nathorn Chaiyakunapruk Omar Y. Mousa Donghee Kim Vincent L. Chen Karn Wijarnpreecha The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019 Journal of Clinical Medicine steatotic liver disease elderly Asia epidemiology geriatrics |
| title | The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019 |
| title_full | The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019 |
| title_fullStr | The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019 |
| title_full_unstemmed | The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019 |
| title_short | The Surreptitious Burden of Nonalcoholic Fatty Liver Disease in the Elderly in the Asia-Pacific Region: An Insight from the Global Burden of Disease Study 2019 |
| title_sort | surreptitious burden of nonalcoholic fatty liver disease in the elderly in the asia pacific region an insight from the global burden of disease study 2019 |
| topic | steatotic liver disease elderly Asia epidemiology geriatrics |
| url | https://www.mdpi.com/2077-0383/12/20/6456 |
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