Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes
Introduction: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among dif...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2023-01-01
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| Series: | Liver Cancer |
| Online Access: | https://www.karger.com/Article/FullText/527498 |
| _version_ | 1797896478011686912 |
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| author | Wen-jia Cai Minghua Ying Rong-qin Zheng Jintang Liao Baoming Luo Lina Tang Wen Cheng Hong Yang An Wei Yilin Yang Hui Wang Yan-chun Luo Cun Liu Hui Zhong Qi Yang Jie Yu Ping Liang |
| author_facet | Wen-jia Cai Minghua Ying Rong-qin Zheng Jintang Liao Baoming Luo Lina Tang Wen Cheng Hong Yang An Wei Yilin Yang Hui Wang Yan-chun Luo Cun Liu Hui Zhong Qi Yang Jie Yu Ping Liang |
| author_sort | Wen-jia Cai |
| collection | DOAJ |
| description | Introduction: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection.
Methods: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67 and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI- RADS categories were further analyzed.
Results: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection.
Conclusions: Biological characteristics of HCC, including differentiation and level of Ki-67 expression could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection. |
| first_indexed | 2024-04-10T07:42:29Z |
| format | Article |
| id | doaj.art-97aab616c0b94893b0c0e680deb813d2 |
| institution | Directory Open Access Journal |
| issn | 2235-1795 1664-5553 |
| language | English |
| last_indexed | 2024-04-10T07:42:29Z |
| publishDate | 2023-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Liver Cancer |
| spelling | doaj.art-97aab616c0b94893b0c0e680deb813d22023-02-23T11:31:01ZengKarger PublishersLiver Cancer2235-17951664-55532023-01-01110.1159/000527498527498Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomesWen-jia CaiMinghua YingRong-qin ZhengJintang LiaoBaoming LuoLina TangWen ChengHong YangAn Weihttps://orcid.org/0000-0002-8625-4209Yilin YangHui WangYan-chun LuoCun LiuHui ZhongQi YangJie YuPing Lianghttps://orcid.org/0000-0001-8933-6392Introduction: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection. Methods: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67 and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI- RADS categories were further analyzed. Results: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection. Conclusions: Biological characteristics of HCC, including differentiation and level of Ki-67 expression could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection.https://www.karger.com/Article/FullText/527498 |
| spellingShingle | Wen-jia Cai Minghua Ying Rong-qin Zheng Jintang Liao Baoming Luo Lina Tang Wen Cheng Hong Yang An Wei Yilin Yang Hui Wang Yan-chun Luo Cun Liu Hui Zhong Qi Yang Jie Yu Ping Liang Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes Liver Cancer |
| title | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes |
| title_full | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes |
| title_fullStr | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes |
| title_full_unstemmed | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes |
| title_short | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes |
| title_sort | contrast enhanced ultrasound liver imaging reporting and data system li rads in hepatocellular carcinoma ≤ 5cm biological characteristics and patient outcomes |
| url | https://www.karger.com/Article/FullText/527498 |
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