Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

The balance between self-renewal and differentiation of neural progenitor cells (NPCs) dictates neurogenesis and proper brain development. We found that the RNA- binding protein Sam68 (Khdrbs1) is strongly expressed in neurogenic areas of the neocortex and supports the self-renewing potential of mou...

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Bibliographic Details
Main Authors: Piergiorgio La Rosa, Pamela Bielli, Claudia Compagnucci, Eleonora Cesari, Elisabetta Volpe, Stefano Farioli Vecchioli, Claudio Sette
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
Sam68
pre-mRNA processing
alternative splicing
ALDH1A3
neural progenitor cells
glycolytic metabolism
Online Access:https://elifesciences.org/articles/20750

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