High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study
Objective: The aim of this study was to elaborate the link of thyroid hormones (THs) and metabolic syndrome (MetS) in a Chinese euthyroid employee popul ation with MetS component(s). Methods: An annual health checkup was performed on employees in 2019. Anthropometric parameters, metabolic paramete...
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| Natura: | Articolo |
| Lingua: | English |
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Bioscientifica
2023-05-01
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| Serie: | Endocrine Connections |
| Soggetti: | |
| Accesso online: | https://ec.bioscientifica.com/view/journals/ec/12/5/EC-22-0424.xml |
| _version_ | 1827955941812731904 |
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| author | Qiankai Jin Guoqing Huang Xiaoqing Tian Yimeng Shu Ximisinuer Tusongtuoheti Yushan Mao |
| author_facet | Qiankai Jin Guoqing Huang Xiaoqing Tian Yimeng Shu Ximisinuer Tusongtuoheti Yushan Mao |
| author_sort | Qiankai Jin |
| collection | DOAJ |
| description | Objective: The aim of this study was to elaborate the link of thyroid hormones (THs) and metabolic syndrome (MetS) in a Chinese euthyroid employee popul ation with MetS component(s).
Methods: An annual health checkup was performed on employees in 2019. Anthropometric parameters, metabolic parameters, and thyroid function were measured. A questionnaire was used in conjunction with Zhenhai Lianhua Hospital database to receive employees' medication records and thyroid s urgical history records.
Results: A total of 5486 eligible employees were included; the prevalen ce of MetS was generally higher in males than in females (38.9 vs. 30.4%, P < 0.001). Among employees with central obesity, hypertriglyceridemia, hyperglycemia, hypertension, and low high-density lipoprotein cholesterol (HDL-C), the prevalence of MetS was 68.8, 63.6, 68.2, 48.8, and 60.0% in males and 72.6, 63.3, 61.3, 42.3, and 42.3% in females, respectively. Logistic regression analysis showed that thyroid-stimulating hormone and free thyroxine (FT4) quartiles had no significant impact on MetS. Free triiodot hyronine/free thyroxine (FT3/FT4) and free triiodothyronine (FT3)) quartiles were posit ively associated with the increased odds ratio (OR) for MetS and dyslipidemia (hypertrigl yceridemia and low HDL-C), regardless of gender. In males, FT3 and FT3/FT4 quartil es were positively associated with the OR for central obesity, whereas FT4 quartil es were negatively associated; both FT3 and FT4 quartiles were positively associat ed with increased OR of hyperglycemia, while similar results were not observed in femal es. Interaction analysis indicated no significant effect of gender and TH interactions on risk of MetS.
Conclusion: High FT3 and FT3/FT4 were strongly linked with MetS and dyslip idemia in our study, even in the euthyroid individuals. Tighter control of th yroid function was necessary for those with preexisting MetS component(s). |
| first_indexed | 2024-04-09T14:55:33Z |
| format | Article |
| id | doaj.art-97abaf872a1841ed92125d227bcbeb82 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-09T14:55:33Z |
| publishDate | 2023-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-97abaf872a1841ed92125d227bcbeb822023-05-02T05:53:12ZengBioscientificaEndocrine Connections2049-36142023-05-01125112https://doi.org/10.1530/EC-22-0424High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai studyQiankai Jin0Guoqing Huang1Xiaoqing Tian2Yimeng Shu3Ximisinuer Tusongtuoheti4Yushan Mao5Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, ChinaObjective: The aim of this study was to elaborate the link of thyroid hormones (THs) and metabolic syndrome (MetS) in a Chinese euthyroid employee popul ation with MetS component(s). Methods: An annual health checkup was performed on employees in 2019. Anthropometric parameters, metabolic parameters, and thyroid function were measured. A questionnaire was used in conjunction with Zhenhai Lianhua Hospital database to receive employees' medication records and thyroid s urgical history records. Results: A total of 5486 eligible employees were included; the prevalen ce of MetS was generally higher in males than in females (38.9 vs. 30.4%, P < 0.001). Among employees with central obesity, hypertriglyceridemia, hyperglycemia, hypertension, and low high-density lipoprotein cholesterol (HDL-C), the prevalence of MetS was 68.8, 63.6, 68.2, 48.8, and 60.0% in males and 72.6, 63.3, 61.3, 42.3, and 42.3% in females, respectively. Logistic regression analysis showed that thyroid-stimulating hormone and free thyroxine (FT4) quartiles had no significant impact on MetS. Free triiodot hyronine/free thyroxine (FT3/FT4) and free triiodothyronine (FT3)) quartiles were posit ively associated with the increased odds ratio (OR) for MetS and dyslipidemia (hypertrigl yceridemia and low HDL-C), regardless of gender. In males, FT3 and FT3/FT4 quartil es were positively associated with the OR for central obesity, whereas FT4 quartil es were negatively associated; both FT3 and FT4 quartiles were positively associat ed with increased OR of hyperglycemia, while similar results were not observed in femal es. Interaction analysis indicated no significant effect of gender and TH interactions on risk of MetS. Conclusion: High FT3 and FT3/FT4 were strongly linked with MetS and dyslip idemia in our study, even in the euthyroid individuals. Tighter control of th yroid function was necessary for those with preexisting MetS component(s).https://ec.bioscientifica.com/view/journals/ec/12/5/EC-22-0424.xmleuthyroidthyroid stimulating hormonefree triiodothyroninefree thyroxinemetabolic syndrome |
| spellingShingle | Qiankai Jin Guoqing Huang Xiaoqing Tian Yimeng Shu Ximisinuer Tusongtuoheti Yushan Mao High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study Endocrine Connections euthyroid thyroid stimulating hormone free triiodothyronine free thyroxine metabolic syndrome |
| title | High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study |
| title_full | High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study |
| title_fullStr | High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study |
| title_full_unstemmed | High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study |
| title_short | High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study |
| title_sort | high free triiodothyronine and free triiodothyronine to free thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population the zhejiang zhenhai study |
| topic | euthyroid thyroid stimulating hormone free triiodothyronine free thyroxine metabolic syndrome |
| url | https://ec.bioscientifica.com/view/journals/ec/12/5/EC-22-0424.xml |
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