Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI
Abstract Background The three-dimensional chemical exchange saturation transfer (3D CEST) technique is a novel and promising magnetic resonance sequence; however, its application in nasopharyngeal carcinoma (NPC) lacks sufficient evaluation. This study aimed to assess the feasibility of the 3D CEST...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-023-00602-6 |
| _version_ | 1797451701155790848 |
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| author | Wenguang Liu Xiao Wang Simin Xie Weiyin Vivian Liu Ismail Bilal Masokano Yu Bai Juan Chen Linhui Zhong Yijing Luo Gaofeng Zhou Wenzheng Li Yigang Pei |
| author_facet | Wenguang Liu Xiao Wang Simin Xie Weiyin Vivian Liu Ismail Bilal Masokano Yu Bai Juan Chen Linhui Zhong Yijing Luo Gaofeng Zhou Wenzheng Li Yigang Pei |
| author_sort | Wenguang Liu |
| collection | DOAJ |
| description | Abstract Background The three-dimensional chemical exchange saturation transfer (3D CEST) technique is a novel and promising magnetic resonance sequence; however, its application in nasopharyngeal carcinoma (NPC) lacks sufficient evaluation. This study aimed to assess the feasibility of the 3D CEST technique in predicting the short-term treatment outcomes for chemoradiotherapy (CRT) in NPC patients. Methods Forty NPC patients and fourteen healthy volunteers were enrolled and underwent the pre-treatment 3D CEST magnetic resonance imaging and diffusion-weighted imaging (DWI). The reliability of 3D CEST was assessed in healthy volunteers by calculating the intra- and inter-observer correlation coefficient (ICC) for amide proton transfer weighted-signal intensity (APTw-SI) and magnetization transfer ratio (MTR) values. NPC patients were divided into residual and non-residual groups based on short-term treatment outcomes after CRT. Whole-tumor regions of interest (ROIs) were manually drawn to measure APTw-SI, MTR and apparent diffusion coefficient (ADC) values. Multivariate analysis and the receiver operating characteristic curve (ROC) were used to evaluate the prediction performance of clinical characteristics, APTw-SI, MTR, ADC values, and combined models in predicting short-term treatment outcomes in NPC patients. Results For the healthy volunteer group, all APTw-SI and MTR values exhibited good to excellent intra- and inter-observer agreements (0.736–0.910, 0.895–0.981, all P > 0.05). For NPC patients, MTR values showed a significant difference between the non-residual and residual groups (31.24 ± 5.21% vs. 34.74 ± 1.54%, P = 0.003) while no significant differences were observed for APTw-SI and ADC values (P > 0.05). Moreover, the diagnostic power of MTR value was superior to APTw-SI (AUC: 0.818 vs. 0.521, P = 0.017) and comparable to ADC values (AUC: 0.818 vs. 0.649, P > 0.05) in predicting short-term treatment outcomes for NPC patients. The prediction performance did not improve even when combining MTR values with APTw-SI and/or ADC values (P > 0.05). Conclusions The pre-treatment MTR value acquired through 3D CEST demonstrated superior predictive performance for short-term treatment outcomes compared to APTw-SI and ADC values in NPC patients after CRT. |
| first_indexed | 2024-03-09T14:57:19Z |
| format | Article |
| id | doaj.art-97ad107e107042a59f58deb0e16438a2 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-03-09T14:57:19Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-97ad107e107042a59f58deb0e16438a22023-11-26T14:06:20ZengBMCCancer Imaging1470-73302023-09-0123111310.1186/s40644-023-00602-6Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRIWenguang Liu0Xiao Wang1Simin Xie2Weiyin Vivian Liu3Ismail Bilal Masokano4Yu Bai5Juan Chen6Linhui Zhong7Yijing Luo8Gaofeng Zhou9Wenzheng Li10Yigang Pei11Department of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityMR Research, GE HealthcareDepartment of Radiology, The Third Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Radiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityAbstract Background The three-dimensional chemical exchange saturation transfer (3D CEST) technique is a novel and promising magnetic resonance sequence; however, its application in nasopharyngeal carcinoma (NPC) lacks sufficient evaluation. This study aimed to assess the feasibility of the 3D CEST technique in predicting the short-term treatment outcomes for chemoradiotherapy (CRT) in NPC patients. Methods Forty NPC patients and fourteen healthy volunteers were enrolled and underwent the pre-treatment 3D CEST magnetic resonance imaging and diffusion-weighted imaging (DWI). The reliability of 3D CEST was assessed in healthy volunteers by calculating the intra- and inter-observer correlation coefficient (ICC) for amide proton transfer weighted-signal intensity (APTw-SI) and magnetization transfer ratio (MTR) values. NPC patients were divided into residual and non-residual groups based on short-term treatment outcomes after CRT. Whole-tumor regions of interest (ROIs) were manually drawn to measure APTw-SI, MTR and apparent diffusion coefficient (ADC) values. Multivariate analysis and the receiver operating characteristic curve (ROC) were used to evaluate the prediction performance of clinical characteristics, APTw-SI, MTR, ADC values, and combined models in predicting short-term treatment outcomes in NPC patients. Results For the healthy volunteer group, all APTw-SI and MTR values exhibited good to excellent intra- and inter-observer agreements (0.736–0.910, 0.895–0.981, all P > 0.05). For NPC patients, MTR values showed a significant difference between the non-residual and residual groups (31.24 ± 5.21% vs. 34.74 ± 1.54%, P = 0.003) while no significant differences were observed for APTw-SI and ADC values (P > 0.05). Moreover, the diagnostic power of MTR value was superior to APTw-SI (AUC: 0.818 vs. 0.521, P = 0.017) and comparable to ADC values (AUC: 0.818 vs. 0.649, P > 0.05) in predicting short-term treatment outcomes for NPC patients. The prediction performance did not improve even when combining MTR values with APTw-SI and/or ADC values (P > 0.05). Conclusions The pre-treatment MTR value acquired through 3D CEST demonstrated superior predictive performance for short-term treatment outcomes compared to APTw-SI and ADC values in NPC patients after CRT.https://doi.org/10.1186/s40644-023-00602-6Chemical exchange saturation transferMagnetization transferAmide proton transfer imagingNasopharyngeal carcinomaChemoradiotherapy |
| spellingShingle | Wenguang Liu Xiao Wang Simin Xie Weiyin Vivian Liu Ismail Bilal Masokano Yu Bai Juan Chen Linhui Zhong Yijing Luo Gaofeng Zhou Wenzheng Li Yigang Pei Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI Cancer Imaging Chemical exchange saturation transfer Magnetization transfer Amide proton transfer imaging Nasopharyngeal carcinoma Chemoradiotherapy |
| title | Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI |
| title_full | Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI |
| title_fullStr | Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI |
| title_full_unstemmed | Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI |
| title_short | Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI |
| title_sort | amide proton transfer apt and magnetization transfer mt in predicting short term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy a feasibility study of three dimensional chemical exchange saturation transfer cest mri |
| topic | Chemical exchange saturation transfer Magnetization transfer Amide proton transfer imaging Nasopharyngeal carcinoma Chemoradiotherapy |
| url | https://doi.org/10.1186/s40644-023-00602-6 |
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