Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease
Aim. To reveal the association between disorders of myocardial blood flow and reserve, according to dynamic single photon emission computed tomography (SPECT), with risk factors for cardiovascular diseases (CVD) in patients with nonobstructive coronary artery disease (CAD).Material and methods. The...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2023-03-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5158 |
| _version_ | 1797856566326591488 |
|---|---|
| author | A. N. Maltseva K. V. Kop’eva A. V. Mochula M. O. Gulya O. N. Dymbrylova E. V. Grakova A. A. Boshchenko K. V. Zavadovsky |
| author_facet | A. N. Maltseva K. V. Kop’eva A. V. Mochula M. O. Gulya O. N. Dymbrylova E. V. Grakova A. A. Boshchenko K. V. Zavadovsky |
| author_sort | A. N. Maltseva |
| collection | DOAJ |
| description | Aim. To reveal the association between disorders of myocardial blood flow and reserve, according to dynamic single photon emission computed tomography (SPECT), with risk factors for cardiovascular diseases (CVD) in patients with nonobstructive coronary artery disease (CAD).Material and methods. The study included patients with suspected stable nonobstructive (<50%) CAD. Based on the survey data, anamnesis, out- and in-patient medical records, we analyzed main CVD risk factors. All patients underwent dynamic myocardial SPECT and analysis of blood lipid profile in vitro. Depending on myocardial flow reserve (MFR), two groups were formed: 1. With reduced MFR <2,0 (rMFR); 2. With normal MFR ≥2,0 (nMFR).Results. The study included 47 patients divided into 2 following groups: the rMFR group consisted of 24 patients (15 men, age 56,3±9,1 years), the nMFR group — 23 patients (13 men, age 58,4±10,7 years). There was no significant difference in prevalence of CVD risk factors in groups. However, dyslipidemia was detected more often in rMFR patients (p=0,053): 58% vs 30%, respectively. In patients with rMFR, there were significantly higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). Correlation analysis revealed significant negative inverse relationships between MFR values with TC (ρ=-0,36, p=0,01) and LDL-C (ρ=-0,38, p=0,009). According to univariate logistic regression, significant predictors of reduced MFR were TC (odds ratio (OR), 2,32; 95% confidence interval (CI), 1,17-4,59; p=0,01) and LDL-C (OR, 2,16; 95% CI, 1,04-4,51; p=0,04). According to a stepwise multivariate logistic regression analysis, only TC was an independent predictor of a decrease in MFR (OR, 2,32; 95% CI, 1,17-4,59; p=0,02).Conclusion. MFR, determined by dynamic SPECT, is associated with TC and LDL-C levels. TC level is an independent predictor of a decrease in MFR. |
| first_indexed | 2024-04-09T20:42:35Z |
| format | Article |
| id | doaj.art-97ad60e94a8947418a129d0b121f0532 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:42:35Z |
| publishDate | 2023-03-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-97ad60e94a8947418a129d0b121f05322023-03-29T21:23:43Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-03-0128210.15829/1560-4071-2023-51583641Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery diseaseA. N. Maltseva0K. V. Kop’eva1A. V. Mochula2M. O. Gulya3O. N. Dymbrylova4E. V. Grakova5A. A. Boshchenko6K. V. Zavadovsky7Cardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterAim. To reveal the association between disorders of myocardial blood flow and reserve, according to dynamic single photon emission computed tomography (SPECT), with risk factors for cardiovascular diseases (CVD) in patients with nonobstructive coronary artery disease (CAD).Material and methods. The study included patients with suspected stable nonobstructive (<50%) CAD. Based on the survey data, anamnesis, out- and in-patient medical records, we analyzed main CVD risk factors. All patients underwent dynamic myocardial SPECT and analysis of blood lipid profile in vitro. Depending on myocardial flow reserve (MFR), two groups were formed: 1. With reduced MFR <2,0 (rMFR); 2. With normal MFR ≥2,0 (nMFR).Results. The study included 47 patients divided into 2 following groups: the rMFR group consisted of 24 patients (15 men, age 56,3±9,1 years), the nMFR group — 23 patients (13 men, age 58,4±10,7 years). There was no significant difference in prevalence of CVD risk factors in groups. However, dyslipidemia was detected more often in rMFR patients (p=0,053): 58% vs 30%, respectively. In patients with rMFR, there were significantly higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). Correlation analysis revealed significant negative inverse relationships between MFR values with TC (ρ=-0,36, p=0,01) and LDL-C (ρ=-0,38, p=0,009). According to univariate logistic regression, significant predictors of reduced MFR were TC (odds ratio (OR), 2,32; 95% confidence interval (CI), 1,17-4,59; p=0,01) and LDL-C (OR, 2,16; 95% CI, 1,04-4,51; p=0,04). According to a stepwise multivariate logistic regression analysis, only TC was an independent predictor of a decrease in MFR (OR, 2,32; 95% CI, 1,17-4,59; p=0,02).Conclusion. MFR, determined by dynamic SPECT, is associated with TC and LDL-C levels. TC level is an independent predictor of a decrease in MFR.https://russjcardiol.elpub.ru/jour/article/view/5158microvascular dysfunctionnonobstructive coronary artery diseaserisk factorsdyslipidemiamyocardial flow reservespect |
| spellingShingle | A. N. Maltseva K. V. Kop’eva A. V. Mochula M. O. Gulya O. N. Dymbrylova E. V. Grakova A. A. Boshchenko K. V. Zavadovsky Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease Российский кардиологический журнал microvascular dysfunction nonobstructive coronary artery disease risk factors dyslipidemia myocardial flow reserve spect |
| title | Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease |
| title_full | Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease |
| title_fullStr | Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease |
| title_full_unstemmed | Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease |
| title_short | Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease |
| title_sort | association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease |
| topic | microvascular dysfunction nonobstructive coronary artery disease risk factors dyslipidemia myocardial flow reserve spect |
| url | https://russjcardiol.elpub.ru/jour/article/view/5158 |
| work_keys_str_mv | AT anmaltseva associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease AT kvkopeva associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease AT avmochula associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease AT mogulya associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease AT ondymbrylova associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease AT evgrakova associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease AT aaboshchenko associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease AT kvzavadovsky associationofimpairedmyocardialflowreservewithriskfactorsforcardiovasculardiseasesinpatientswithnonobstructivecoronaryarterydisease |