Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells
Conventional dentistry faces limitations in preserving tooth health due to the finite lifespan of restorative materials. Regenerative dentistry, utilizing stem cells and bioactive materials, offers a promising approach for regenerating dental tissues. Human dental pulp stem cells (hDPSCs) and bioact...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423002752 |
| _version_ | 1797674146864300032 |
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| author | B. Christie N. Musri N. Djustiana V. Takarini N. Tuygunov M.N. Zakaria A. Cahyanto |
| author_facet | B. Christie N. Musri N. Djustiana V. Takarini N. Tuygunov M.N. Zakaria A. Cahyanto |
| author_sort | B. Christie |
| collection | DOAJ |
| description | Conventional dentistry faces limitations in preserving tooth health due to the finite lifespan of restorative materials. Regenerative dentistry, utilizing stem cells and bioactive materials, offers a promising approach for regenerating dental tissues. Human dental pulp stem cells (hDPSCs) and bioactive materials like calcium phosphate (CaP) and silicate-based materials have shown potential for dental tissue regeneration. This systematic review aims to investigate the effects of CaP and silicate-based materials on hDPSCs through in vitro studies published since 2015. Following the PRISMA guidelines, a comprehensive search strategy was implemented in PubMed MedLine, Cochrane, and ScienceDirect databases. Eligibility criteria were established using the PICOS scheme. Data extraction and risk of bias (RoB) assessment were conducted, with the included studies assessed for bias using the Office of Health and Translation (OHAT) RoB tool. The research has been registered at OSF Registries. Ten in vitro studies met the eligibility criteria out of 1088 initial studies. Methodological heterogeneity and the use of self-synthesized biomaterials with limited generalizability were observed in the included study. The findings highlight the positive effect of CaP and silicate-based materials on hDPSCs viability, adhesion, migration, proliferation, and differentiation. While the overall RoB assessment indicated satisfactory credibility of the reviewed studies, the limited number of studies and methodological heterogeneity pose challenges for quantitative research. In conclusion, this systematic review provides valuable insights into the effects of CaP and silicate-based materials on hDPSCs. Further research is awaited to enhance our understanding and optimize regenerative dental treatments using bioactive materials and hDPSCs, which promise to improve patient outcomes. |
| first_indexed | 2024-03-11T21:54:53Z |
| format | Article |
| id | doaj.art-97ada9f6a5084a99b2860161cb4f83df |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-11T21:54:53Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-97ada9f6a5084a99b2860161cb4f83df2023-09-26T04:12:19ZengElsevierMaterials Today Bio2590-00642023-12-0123100815Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cellsB. Christie0N. Musri1N. Djustiana2V. Takarini3N. Tuygunov4M.N. Zakaria5A. Cahyanto6Faculty of Dentistry, Universitas Padjadjaran, Jalan Sekeloa Selatan 1, Bandung, 40134, IndonesiaFaculty of Dentistry, Universitas Padjadjaran, Jalan Sekeloa Selatan 1, Bandung, 40134, IndonesiaDepartment of Dental Materials Science and Technology, Faculty of Dentistry, Universitas Padjadjaran, Jalan Raya Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia; Oral Biomaterials Study Center, Faculty of Dentistry, Universitas Padjadjaran, Jalan Sekeloa Selatan 1, Bandung, 40134, IndonesiaDepartment of Dental Materials Science and Technology, Faculty of Dentistry, Universitas Padjadjaran, Jalan Raya Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia; Oral Biomaterials Study Center, Faculty of Dentistry, Universitas Padjadjaran, Jalan Sekeloa Selatan 1, Bandung, 40134, IndonesiaFaculty of Dentistry, Universiti Malaya, Kuala Lumpur, 50603, MalaysiaDepartment of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, 50603, MalaysiaDepartment of Dental Materials Science and Technology, Faculty of Dentistry, Universitas Padjadjaran, Jalan Raya Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia; Oral Biomaterials Study Center, Faculty of Dentistry, Universitas Padjadjaran, Jalan Sekeloa Selatan 1, Bandung, 40134, Indonesia; Functional Nano Powder University Center of Excellence (FiNder U CoE), Universitas Padjadjaran, Jalan Raya Bandung-Sumedang Km 21, Jatinangor, 45363, Indonesia; Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, 50603, Malaysia; Corresponding author.Department of Dental Materials Science and Technology, Faculty of Dentistry, Universitas Padjadjaran, Jalan Raya Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia.Conventional dentistry faces limitations in preserving tooth health due to the finite lifespan of restorative materials. Regenerative dentistry, utilizing stem cells and bioactive materials, offers a promising approach for regenerating dental tissues. Human dental pulp stem cells (hDPSCs) and bioactive materials like calcium phosphate (CaP) and silicate-based materials have shown potential for dental tissue regeneration. This systematic review aims to investigate the effects of CaP and silicate-based materials on hDPSCs through in vitro studies published since 2015. Following the PRISMA guidelines, a comprehensive search strategy was implemented in PubMed MedLine, Cochrane, and ScienceDirect databases. Eligibility criteria were established using the PICOS scheme. Data extraction and risk of bias (RoB) assessment were conducted, with the included studies assessed for bias using the Office of Health and Translation (OHAT) RoB tool. The research has been registered at OSF Registries. Ten in vitro studies met the eligibility criteria out of 1088 initial studies. Methodological heterogeneity and the use of self-synthesized biomaterials with limited generalizability were observed in the included study. The findings highlight the positive effect of CaP and silicate-based materials on hDPSCs viability, adhesion, migration, proliferation, and differentiation. While the overall RoB assessment indicated satisfactory credibility of the reviewed studies, the limited number of studies and methodological heterogeneity pose challenges for quantitative research. In conclusion, this systematic review provides valuable insights into the effects of CaP and silicate-based materials on hDPSCs. Further research is awaited to enhance our understanding and optimize regenerative dental treatments using bioactive materials and hDPSCs, which promise to improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S2590006423002752Calcium phosphateSilicatesRegenerative medicineDental pulpStem cells |
| spellingShingle | B. Christie N. Musri N. Djustiana V. Takarini N. Tuygunov M.N. Zakaria A. Cahyanto Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells Materials Today Bio Calcium phosphate Silicates Regenerative medicine Dental pulp Stem cells |
| title | Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells |
| title_full | Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells |
| title_fullStr | Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells |
| title_full_unstemmed | Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells |
| title_short | Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells |
| title_sort | advances and challenges in regenerative dentistry a systematic review of calcium phosphate and silicate based materials on human dental pulp stem cells |
| topic | Calcium phosphate Silicates Regenerative medicine Dental pulp Stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423002752 |
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